Yersinia pestis evolution on a small timescale: Comparison of whole genome sequences from North America

Raymond K. Auerbach, Apichai Tuanyok, William S. Probert, Leo Kenefic, Amy J. Vogler, David C. Bruce, Christine Munk, Thomas S. Brettin, Mark Eppinger, Jacques Ravel, David M Wagner, Paul S Keim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background. Yersinia pestis, the etiologic agent of plague, was responsible for several devastating epidemics throughout history and is currently of global importance to current public heath and biodefense efforts. Y. pestis is widespread in the Western United States. Because Y. pestis was first introduced to this region just over 100 years ago, there has been little time for genetic diversity to accumulate. Recent studies based upon single nucleotide polymorphisms have begun to quantify the genetic diversity of Y. pestis in North America. Methodology/Principal Findings. To examine the evolution of Y. pestis in North America, a gapped genome sequence of CA88-4125 was generated. Sequence comparison with another North American Y. pestis strain, CO92, identified seven regions of difference (six inversions, one rearrangement), differing IS element copy numbers, and several SNP5. Conclusions/Significance. The relatively large number of inverted/ rearranged segments suggests that North American Y. pestis strains may be undergoing inversion fixation at high rates over a short time span, contributing to higher-than-expected diversity in this region. These findings will hopefully encourage the scientific community to sequence additional Y. pestis strains from North America and abroad, leading to a greater understanding of the evolutionary history of this pathogen.

Original languageEnglish (US)
Article numbere770
JournalPLoS One
Volume2
Issue number8
DOIs
StatePublished - Aug 22 2007

Fingerprint

Yersinia pestis
North America
Genes
Genome
genome
DNA Transposable Elements
Pathogens
Polymorphism
Nucleotides
History
genetic variation
history
Plague
plague
Western United States
single nucleotide polymorphism
Single Nucleotide Polymorphism
pathogens

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Yersinia pestis evolution on a small timescale : Comparison of whole genome sequences from North America. / Auerbach, Raymond K.; Tuanyok, Apichai; Probert, William S.; Kenefic, Leo; Vogler, Amy J.; Bruce, David C.; Munk, Christine; Brettin, Thomas S.; Eppinger, Mark; Ravel, Jacques; Wagner, David M; Keim, Paul S.

In: PLoS One, Vol. 2, No. 8, e770, 22.08.2007.

Research output: Contribution to journalArticle

Auerbach, RK, Tuanyok, A, Probert, WS, Kenefic, L, Vogler, AJ, Bruce, DC, Munk, C, Brettin, TS, Eppinger, M, Ravel, J, Wagner, DM & Keim, PS 2007, 'Yersinia pestis evolution on a small timescale: Comparison of whole genome sequences from North America', PLoS One, vol. 2, no. 8, e770. https://doi.org/10.1371/journal.pone.0000770
Auerbach, Raymond K. ; Tuanyok, Apichai ; Probert, William S. ; Kenefic, Leo ; Vogler, Amy J. ; Bruce, David C. ; Munk, Christine ; Brettin, Thomas S. ; Eppinger, Mark ; Ravel, Jacques ; Wagner, David M ; Keim, Paul S. / Yersinia pestis evolution on a small timescale : Comparison of whole genome sequences from North America. In: PLoS One. 2007 ; Vol. 2, No. 8.
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