What is the role of titin in active muscle?

Jenna A. Monroy, Krysta L. Powers, Leslie A. Gilmore, Theodore A. Uyeno, Stan L Lindstedt, Kiisa C Nishikawa

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Several properties of muscle defy explanation solely based on the sliding filament-swinging cross-bridge theory. Indeed, muscle behaves as though there is a dynamic "spring" within the sarcomeres. We propose a new "winding filament" mechanism for how titin acts, in conjunction with the cross-bridges, as a force-dependent spring. The addition of titin into active sarcomeres resolves many puzzling muscle characteristics.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalExercise and Sport Sciences Reviews
Volume40
Issue number2
DOIs
StatePublished - Apr 2012

Fingerprint

Connectin
Sarcomeres
Muscles

Keywords

  • Connectin
  • force depression
  • force enhancement
  • history dependence
  • sliding filament theory
  • thin filament rotation
  • titin-actin interactions

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

What is the role of titin in active muscle? / Monroy, Jenna A.; Powers, Krysta L.; Gilmore, Leslie A.; Uyeno, Theodore A.; Lindstedt, Stan L; Nishikawa, Kiisa C.

In: Exercise and Sport Sciences Reviews, Vol. 40, No. 2, 04.2012, p. 73-78.

Research output: Contribution to journalArticle

Monroy, Jenna A. ; Powers, Krysta L. ; Gilmore, Leslie A. ; Uyeno, Theodore A. ; Lindstedt, Stan L ; Nishikawa, Kiisa C. / What is the role of titin in active muscle?. In: Exercise and Sport Sciences Reviews. 2012 ; Vol. 40, No. 2. pp. 73-78.
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