Viral detection using an embedded piezoresistive microcantilever sensor

R. L. Gunter, William G Delinger, K. Manygoats, A. Kooser, T. L. Porter

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The detection of aerosol-based vaccinia virus and solution-based vaccinia virus has been studied using a new type of microsensor design. In the embedded piezoresistive microcantilever (EPM) sensor, a tiny piezoresistive microcantilever is embedded or partially embedded into an active sensing material whose volumetric response to the presence of an analyte is recorded as a strain in the cantilever, and subsequent change in the resistance of the cantilever. In one set of experiments, a composite consisting of poly(ethylene oxide), or PEO, combined with vaccinia antibody was used as the active sensing material. In aerosol exposures, this sensor produced a distinct signal owing to vaccinia virus adsorption/incorporation. In addition, experiments using a piezoresistive microcantilever in direct contact with a pure antibody layer in solution were also performed to detect vaccinia virus in solution. Again, a clear and distinct analyte signals obtained.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalSensors and Actuators, A: Physical
Volume107
Issue number3
DOIs
StatePublished - Nov 1 2003

Fingerprint

viruses
Viruses
sensors
Sensors
Polyethylene oxides
Aerosols
antibodies
Antibodies
aerosols
Microsensors
ethylene oxide
Contacts (fluid mechanics)
Experiments
Adsorption
adsorption
composite materials
Composite materials

Keywords

  • Embedded
  • Microcantilever
  • Piezoresistive
  • Vaccinia

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Instrumentation

Cite this

Viral detection using an embedded piezoresistive microcantilever sensor. / Gunter, R. L.; Delinger, William G; Manygoats, K.; Kooser, A.; Porter, T. L.

In: Sensors and Actuators, A: Physical, Vol. 107, No. 3, 01.11.2003, p. 219-224.

Research output: Contribution to journalArticle

Gunter, R. L. ; Delinger, William G ; Manygoats, K. ; Kooser, A. ; Porter, T. L. / Viral detection using an embedded piezoresistive microcantilever sensor. In: Sensors and Actuators, A: Physical. 2003 ; Vol. 107, No. 3. pp. 219-224.
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