Vestibular dysfunction in Gulf War syndrome

Peter S. Roland, Robert W. Haley, Mary W Yellin, Kris Owens, Angela G. Shoup

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

METHODS: Vestibular complaints of Gulf War veterans were characterized by a nested case-control study of 23 veterans with 3 different Gulf War syndromes and 20 matched control subjects. All subjects completed a standardized symptom questionnaire and underwent standard audiovestibular tests administered by audiologists blinded to group identities. RESULTS: The prevalence of reported dizzy spells was higher in veterans with Gulf War syndromes 1 (100%), 2 (85%), and 3 (100%) than in controls (25%, P < 0.0001). Dizzy spells were more frequent, lasted longer, and involved a wider variety of accompanying symptoms in veterans with syndrome 2 than in those with syndromes 1 and 3. Audiovestibular testing showed greater interocular asymmetry of nystagmic velocity on sinusoidal harmonic acceleration in syndromes 1 (P= 0.015) and 2 (P= 0.002), greater asymmetry of saccadic velocity in syndrome 2 (P = 0.4), diminished nystagmic velocity after caloric stimulation bilaterally in syndrome 3 (P =0.02 to 0.04), more subjects with pathologic nystagmus (P = 0.09), and greater interside asymmetry of wave I to III interpeak latency on auditory brain stem response in syndromes 1 (P = 0.005) and 2 (P = 0.07). Asymmetry of gain on sinusoidal harmonic acceleration and pathologic nystagmus were most strongly associated with symptoms of paroxysmal vertigo (P = 0.002 and 0.07, respectively); asymmetry of saccadic velocity, with the severity of vertigo (P = 0.004); and abnormal caloric response, with chronic dysequilibrium (P = 0.006). CONCLUSIONS: The findings are compatible with a subtle neurologic injury from organophosphate- induced delayed neurotoxicity.

Original languageEnglish (US)
Pages (from-to)319-329
Number of pages11
JournalOtolaryngology - Head and Neck Surgery
Volume122
Issue number3
StatePublished - 2000
Externally publishedYes

Fingerprint

Persian Gulf Syndrome
Veterans
Pathologic Nystagmus
Vertigo
Gulf War
Nervous System Trauma
Organophosphates
Brain Stem Auditory Evoked Potentials
Case-Control Studies

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Roland, P. S., Haley, R. W., Yellin, M. W., Owens, K., & Shoup, A. G. (2000). Vestibular dysfunction in Gulf War syndrome. Otolaryngology - Head and Neck Surgery, 122(3), 319-329.

Vestibular dysfunction in Gulf War syndrome. / Roland, Peter S.; Haley, Robert W.; Yellin, Mary W; Owens, Kris; Shoup, Angela G.

In: Otolaryngology - Head and Neck Surgery, Vol. 122, No. 3, 2000, p. 319-329.

Research output: Contribution to journalArticle

Roland, PS, Haley, RW, Yellin, MW, Owens, K & Shoup, AG 2000, 'Vestibular dysfunction in Gulf War syndrome', Otolaryngology - Head and Neck Surgery, vol. 122, no. 3, pp. 319-329.
Roland PS, Haley RW, Yellin MW, Owens K, Shoup AG. Vestibular dysfunction in Gulf War syndrome. Otolaryngology - Head and Neck Surgery. 2000;122(3):319-329.
Roland, Peter S. ; Haley, Robert W. ; Yellin, Mary W ; Owens, Kris ; Shoup, Angela G. / Vestibular dysfunction in Gulf War syndrome. In: Otolaryngology - Head and Neck Surgery. 2000 ; Vol. 122, No. 3. pp. 319-329.
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N2 - METHODS: Vestibular complaints of Gulf War veterans were characterized by a nested case-control study of 23 veterans with 3 different Gulf War syndromes and 20 matched control subjects. All subjects completed a standardized symptom questionnaire and underwent standard audiovestibular tests administered by audiologists blinded to group identities. RESULTS: The prevalence of reported dizzy spells was higher in veterans with Gulf War syndromes 1 (100%), 2 (85%), and 3 (100%) than in controls (25%, P < 0.0001). Dizzy spells were more frequent, lasted longer, and involved a wider variety of accompanying symptoms in veterans with syndrome 2 than in those with syndromes 1 and 3. Audiovestibular testing showed greater interocular asymmetry of nystagmic velocity on sinusoidal harmonic acceleration in syndromes 1 (P= 0.015) and 2 (P= 0.002), greater asymmetry of saccadic velocity in syndrome 2 (P = 0.4), diminished nystagmic velocity after caloric stimulation bilaterally in syndrome 3 (P =0.02 to 0.04), more subjects with pathologic nystagmus (P = 0.09), and greater interside asymmetry of wave I to III interpeak latency on auditory brain stem response in syndromes 1 (P = 0.005) and 2 (P = 0.07). Asymmetry of gain on sinusoidal harmonic acceleration and pathologic nystagmus were most strongly associated with symptoms of paroxysmal vertigo (P = 0.002 and 0.07, respectively); asymmetry of saccadic velocity, with the severity of vertigo (P = 0.004); and abnormal caloric response, with chronic dysequilibrium (P = 0.006). CONCLUSIONS: The findings are compatible with a subtle neurologic injury from organophosphate- induced delayed neurotoxicity.

AB - METHODS: Vestibular complaints of Gulf War veterans were characterized by a nested case-control study of 23 veterans with 3 different Gulf War syndromes and 20 matched control subjects. All subjects completed a standardized symptom questionnaire and underwent standard audiovestibular tests administered by audiologists blinded to group identities. RESULTS: The prevalence of reported dizzy spells was higher in veterans with Gulf War syndromes 1 (100%), 2 (85%), and 3 (100%) than in controls (25%, P < 0.0001). Dizzy spells were more frequent, lasted longer, and involved a wider variety of accompanying symptoms in veterans with syndrome 2 than in those with syndromes 1 and 3. Audiovestibular testing showed greater interocular asymmetry of nystagmic velocity on sinusoidal harmonic acceleration in syndromes 1 (P= 0.015) and 2 (P= 0.002), greater asymmetry of saccadic velocity in syndrome 2 (P = 0.4), diminished nystagmic velocity after caloric stimulation bilaterally in syndrome 3 (P =0.02 to 0.04), more subjects with pathologic nystagmus (P = 0.09), and greater interside asymmetry of wave I to III interpeak latency on auditory brain stem response in syndromes 1 (P = 0.005) and 2 (P = 0.07). Asymmetry of gain on sinusoidal harmonic acceleration and pathologic nystagmus were most strongly associated with symptoms of paroxysmal vertigo (P = 0.002 and 0.07, respectively); asymmetry of saccadic velocity, with the severity of vertigo (P = 0.004); and abnormal caloric response, with chronic dysequilibrium (P = 0.006). CONCLUSIONS: The findings are compatible with a subtle neurologic injury from organophosphate- induced delayed neurotoxicity.

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