Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids

Katherine S. Lovejoy, Cynthia A. Corley, Emily K. Cope, Michael C. Valentine, Jeff G. Leid, Geraldine M. Purdy, John S. Wilkes, Andrew T Koppisch, Rico E. Del Sesto

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A new strategy employs amorphous melts of active pharmaceutical agents, which are formed with metal chlorides, including ZnCl 2, through speciation ambiguity. The Lewis acidic, bioinorganic ionic liquid formulations improve shelf life and water solubility and eliminate issues related to crystal polymorphism. This broad-ranging approach produces thermally robust chlorometallate preparations for use as lotions, antibiofilm agents, and in situations without refrigeration.

Original languageEnglish (US)
Pages (from-to)5357-5364
Number of pages8
JournalCrystal Growth and Design
Volume12
Issue number11
DOIs
StatePublished - Nov 7 2012

Fingerprint

Metal halides
Ionic Liquids
metal halides
Ionic liquids
ambiguity
Drug products
polymorphism
Refrigeration
liquids
Polymorphism
Pharmaceutical Preparations
Chlorides
solubility
Solubility
Metals
chlorides
formulations
life (durability)
preparation
Crystals

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Lovejoy, K. S., Corley, C. A., Cope, E. K., Valentine, M. C., Leid, J. G., Purdy, G. M., ... Del Sesto, R. E. (2012). Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids. Crystal Growth and Design, 12(11), 5357-5364. https://doi.org/10.1021/cg300969u

Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids. / Lovejoy, Katherine S.; Corley, Cynthia A.; Cope, Emily K.; Valentine, Michael C.; Leid, Jeff G.; Purdy, Geraldine M.; Wilkes, John S.; Koppisch, Andrew T; Del Sesto, Rico E.

In: Crystal Growth and Design, Vol. 12, No. 11, 07.11.2012, p. 5357-5364.

Research output: Contribution to journalArticle

Lovejoy, KS, Corley, CA, Cope, EK, Valentine, MC, Leid, JG, Purdy, GM, Wilkes, JS, Koppisch, AT & Del Sesto, RE 2012, 'Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids', Crystal Growth and Design, vol. 12, no. 11, pp. 5357-5364. https://doi.org/10.1021/cg300969u
Lovejoy, Katherine S. ; Corley, Cynthia A. ; Cope, Emily K. ; Valentine, Michael C. ; Leid, Jeff G. ; Purdy, Geraldine M. ; Wilkes, John S. ; Koppisch, Andrew T ; Del Sesto, Rico E. / Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids. In: Crystal Growth and Design. 2012 ; Vol. 12, No. 11. pp. 5357-5364.
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