Unexpected relations of historical anthrax strain

M. H. Antwerpen, J. W. Sahl, D. Birdsell, Talima R Pearson, M. J. Pearce, C. Redmond, H. Meyer, Paul S Keim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In 1998, it was claimed that an 80-year-old glass tube intentionally filled with Bacillus anthracis and embedded in a sugar lump as a WWI biological weapon still contained viable spores. Today, genome sequencing of three colonies isolated in 1998 and subjected to phylogenetic analysis surprisingly identified a well-known B. anthracis reference strain isolated in the United States in 1981, pointing to accidental laboratory contamination. IMPORTANCE Next-generation sequencing and subsequent phylogenetic analyses are useful and reliable tools for the classification of recent and historical samples. The reliability of sequences obtained and bioinformatic algorithms has increased in recent years, and research has uncovered the identity of a presumed bioweapon agent as a contaminant.

Original languageEnglish (US)
Article numbere00440-17
JournalmBio
Volume8
Issue number2
DOIs
StatePublished - Mar 1 2017

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Bacillus anthracis
Anthrax
Biological Warfare Agents
Computational Biology
Spores
Glass
Genome
Research

ASJC Scopus subject areas

  • Microbiology
  • Virology

Cite this

Antwerpen, M. H., Sahl, J. W., Birdsell, D., Pearson, T. R., Pearce, M. J., Redmond, C., ... Keim, P. S. (2017). Unexpected relations of historical anthrax strain. mBio, 8(2), [e00440-17]. https://doi.org/10.1128/mBio.00440-17

Unexpected relations of historical anthrax strain. / Antwerpen, M. H.; Sahl, J. W.; Birdsell, D.; Pearson, Talima R; Pearce, M. J.; Redmond, C.; Meyer, H.; Keim, Paul S.

In: mBio, Vol. 8, No. 2, e00440-17, 01.03.2017.

Research output: Contribution to journalArticle

Antwerpen, MH, Sahl, JW, Birdsell, D, Pearson, TR, Pearce, MJ, Redmond, C, Meyer, H & Keim, PS 2017, 'Unexpected relations of historical anthrax strain', mBio, vol. 8, no. 2, e00440-17. https://doi.org/10.1128/mBio.00440-17
Antwerpen MH, Sahl JW, Birdsell D, Pearson TR, Pearce MJ, Redmond C et al. Unexpected relations of historical anthrax strain. mBio. 2017 Mar 1;8(2). e00440-17. https://doi.org/10.1128/mBio.00440-17
Antwerpen, M. H. ; Sahl, J. W. ; Birdsell, D. ; Pearson, Talima R ; Pearce, M. J. ; Redmond, C. ; Meyer, H. ; Keim, Paul S. / Unexpected relations of historical anthrax strain. In: mBio. 2017 ; Vol. 8, No. 2.
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