Abstract
Background: Diabetes damages peripheral tissues; however, its effects on the lung are less known. Lung diffusing capacity (DLCO) is influenced by alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume (VC), both of which are reduced in adults with type 1 diabetes (T1D). Objective: We sought to determine if diabetes duration affects DLCO, DM, VC, and cardiac output (Q). Methods: 24 T1D patients (10.7-52.8 years) and 24 non-diabetic controls were recruited and had DLCO, DM, VC, and Q measured at rest and during exercise (40, 70 and 90% VO2max). Results: When stratified into two groups based on age (young, LCO, DM, VC, or Q (all of which were normalized to body surface area [BSA]) in the young group or in the old group. When stratified by diabetes duration (short duration, 0.33-8.9 years vs. long duration, 9.6-28 years), the T1D patients in the long duration group had lower DLCO/BSA and DM/BSA compared to the controls (p <0.05). There were no differences in any of the variables in the short duration group. Conclusions: This study has shown that duration of diabetes is associated with decrements in diffusing capacity and its components.
| Original language | English (US) |
|---|---|
| Journal | Respiration |
| DOIs | |
| State | Accepted/In press - Jan 13 2016 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Type 1 Diabetes Duration Decreases Pulmonary Diffusing Capacity during Exercise. / Lee, Michelle J.; Coast, Richard J; Hempleman, Steven C; Baldi, J. Christopher.
In: Respiration, 13.01.2016.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Type 1 Diabetes Duration Decreases Pulmonary Diffusing Capacity during Exercise
AU - Lee, Michelle J.
AU - Coast, Richard J
AU - Hempleman, Steven C
AU - Baldi, J. Christopher
PY - 2016/1/13
Y1 - 2016/1/13
N2 - Background: Diabetes damages peripheral tissues; however, its effects on the lung are less known. Lung diffusing capacity (DLCO) is influenced by alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume (VC), both of which are reduced in adults with type 1 diabetes (T1D). Objective: We sought to determine if diabetes duration affects DLCO, DM, VC, and cardiac output (Q). Methods: 24 T1D patients (10.7-52.8 years) and 24 non-diabetic controls were recruited and had DLCO, DM, VC, and Q measured at rest and during exercise (40, 70 and 90% VO2max). Results: When stratified into two groups based on age (young, LCO, DM, VC, or Q (all of which were normalized to body surface area [BSA]) in the young group or in the old group. When stratified by diabetes duration (short duration, 0.33-8.9 years vs. long duration, 9.6-28 years), the T1D patients in the long duration group had lower DLCO/BSA and DM/BSA compared to the controls (p <0.05). There were no differences in any of the variables in the short duration group. Conclusions: This study has shown that duration of diabetes is associated with decrements in diffusing capacity and its components.
AB - Background: Diabetes damages peripheral tissues; however, its effects on the lung are less known. Lung diffusing capacity (DLCO) is influenced by alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume (VC), both of which are reduced in adults with type 1 diabetes (T1D). Objective: We sought to determine if diabetes duration affects DLCO, DM, VC, and cardiac output (Q). Methods: 24 T1D patients (10.7-52.8 years) and 24 non-diabetic controls were recruited and had DLCO, DM, VC, and Q measured at rest and during exercise (40, 70 and 90% VO2max). Results: When stratified into two groups based on age (young, LCO, DM, VC, or Q (all of which were normalized to body surface area [BSA]) in the young group or in the old group. When stratified by diabetes duration (short duration, 0.33-8.9 years vs. long duration, 9.6-28 years), the T1D patients in the long duration group had lower DLCO/BSA and DM/BSA compared to the controls (p <0.05). There were no differences in any of the variables in the short duration group. Conclusions: This study has shown that duration of diabetes is associated with decrements in diffusing capacity and its components.
UR - http://www.scopus.com/inward/record.url?scp=84954424024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954424024&partnerID=8YFLogxK
U2 - 10.1159/000443181
DO - 10.1159/000443181
M3 - Article
C2 - 26756740
AN - SCOPUS:84959091227
JO - Respiration; international review of thoracic diseases
JF - Respiration; international review of thoracic diseases
SN - 0025-7931
ER -