Abstract
Tularemia is a serious, potentially life threatening zoonotic disease. The causative agent, Francisella tularensis, is ubiquitous in the Northern hemisphere, including Alaska, where it was first isolated from a rabbit tick (Haemophysalis leporis-palustris) in 1938. Since then, F. tularensis has been isolated from wildlife and humans throughout the state. Serologic surveys have found measurable antibodies with prevalence ranging from <1% to 50% and 4% to 18% for selected populations of wildlife species and humans, respectively. We reviewed and summarized known literature on tularemia surveillance in Alaska and summarized the epidemiological information on human cases reported to public health officials. Additionally, available F. tularensis isolates from Alaska were analyzed using canonical SNPs and a multi-locus variable-number tandem repeats (VNTR) analysis (MLVA) system. The results show that both F. t. tularensis and F. t. holarctica are present in Alaska and that subtype A.I, the most virulent type, is responsible for most recently reported human clinical cases in the state.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 61 |
| Number of pages | 1 |
| Journal | Acta Veterinaria Scandinavica |
| DOIs | |
| State | Accepted/In press - Nov 18 2011 |
| Externally published | Yes |
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ASJC Scopus subject areas
- veterinary(all)
Cite this
Tularemia in Alaska, 1938-2010. / Hansen, Cristina M.; Vogler, Amy J.; Keim, Paul S; Wagner, David M; Hueffer, Karsten.
In: Acta Veterinaria Scandinavica, 18.11.2011, p. 61.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tularemia in Alaska, 1938-2010
AU - Hansen, Cristina M.
AU - Vogler, Amy J.
AU - Keim, Paul S
AU - Wagner, David M
AU - Hueffer, Karsten
PY - 2011/11/18
Y1 - 2011/11/18
N2 - Tularemia is a serious, potentially life threatening zoonotic disease. The causative agent, Francisella tularensis, is ubiquitous in the Northern hemisphere, including Alaska, where it was first isolated from a rabbit tick (Haemophysalis leporis-palustris) in 1938. Since then, F. tularensis has been isolated from wildlife and humans throughout the state. Serologic surveys have found measurable antibodies with prevalence ranging from <1% to 50% and 4% to 18% for selected populations of wildlife species and humans, respectively. We reviewed and summarized known literature on tularemia surveillance in Alaska and summarized the epidemiological information on human cases reported to public health officials. Additionally, available F. tularensis isolates from Alaska were analyzed using canonical SNPs and a multi-locus variable-number tandem repeats (VNTR) analysis (MLVA) system. The results show that both F. t. tularensis and F. t. holarctica are present in Alaska and that subtype A.I, the most virulent type, is responsible for most recently reported human clinical cases in the state.
AB - Tularemia is a serious, potentially life threatening zoonotic disease. The causative agent, Francisella tularensis, is ubiquitous in the Northern hemisphere, including Alaska, where it was first isolated from a rabbit tick (Haemophysalis leporis-palustris) in 1938. Since then, F. tularensis has been isolated from wildlife and humans throughout the state. Serologic surveys have found measurable antibodies with prevalence ranging from <1% to 50% and 4% to 18% for selected populations of wildlife species and humans, respectively. We reviewed and summarized known literature on tularemia surveillance in Alaska and summarized the epidemiological information on human cases reported to public health officials. Additionally, available F. tularensis isolates from Alaska were analyzed using canonical SNPs and a multi-locus variable-number tandem repeats (VNTR) analysis (MLVA) system. The results show that both F. t. tularensis and F. t. holarctica are present in Alaska and that subtype A.I, the most virulent type, is responsible for most recently reported human clinical cases in the state.
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U2 - 10.1186/1751-0147-53-61
DO - 10.1186/1751-0147-53-61
M3 - Article
C2 - 22099502
AN - SCOPUS:81255178500
SP - 61
JO - Acta Veterinaria Scandinavica
JF - Acta Veterinaria Scandinavica
SN - 1751-0147
ER -