Tularemia in Alaska, 1938 - 2010.

Cristina M. Hansen, Amy J. Vogler, Paul Keim, David M. Wagner, Karsten Hueffer

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Tularemia is a serious, potentially life threatening zoonotic disease. The causative agent, Francisella tularensis, is ubiquitous in the Northern hemisphere, including Alaska, where it was first isolated from a rabbit tick (Haemophysalis leporis-palustris) in 1938. Since then, F. tularensis has been isolated from wildlife and humans throughout the state. Serologic surveys have found measurable antibodies with prevalence ranging from < 1% to 50% and 4% to 18% for selected populations of wildlife species and humans, respectively. We reviewed and summarized known literature on tularemia surveillance in Alaska and summarized the epidemiological information on human cases reported to public health officials. Additionally, available F. tularensis isolates from Alaska were analyzed using canonical SNPs and a multi-locus variable-number tandem repeats (VNTR) analysis (MLVA) system. The results show that both F. t. tularensis and F. t. holarctica are present in Alaska and that subtype A.I, the most virulent type, is responsible for most recently reported human clinical cases in the state.

Original languageEnglish (US)
Number of pages1
JournalActa veterinaria Scandinavica
Volume53
DOIs
StatePublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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