Trivalent antigens for degranulation of mast cells

Richard G Posner, Dianliang Geng, Seth Haymore, James Bogert, Israel Pecht, Arieh Licht, Paul B. Savage

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.

Original languageEnglish (US)
Pages (from-to)3551-3554
Number of pages4
JournalOrganic Letters
Volume9
Issue number18
DOIs
StatePublished - Aug 30 2007

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antigens
Mast Cells
Antigens
Receptor Aggregation
Basophils
Cell Surface Receptors
antibodies
Hypersensitivity
Agglomeration
Molecules
Antibodies
cells
molecules

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Posner, R. G., Geng, D., Haymore, S., Bogert, J., Pecht, I., Licht, A., & Savage, P. B. (2007). Trivalent antigens for degranulation of mast cells. Organic Letters, 9(18), 3551-3554. https://doi.org/10.1021/ol071175h

Trivalent antigens for degranulation of mast cells. / Posner, Richard G; Geng, Dianliang; Haymore, Seth; Bogert, James; Pecht, Israel; Licht, Arieh; Savage, Paul B.

In: Organic Letters, Vol. 9, No. 18, 30.08.2007, p. 3551-3554.

Research output: Contribution to journalArticle

Posner, RG, Geng, D, Haymore, S, Bogert, J, Pecht, I, Licht, A & Savage, PB 2007, 'Trivalent antigens for degranulation of mast cells', Organic Letters, vol. 9, no. 18, pp. 3551-3554. https://doi.org/10.1021/ol071175h
Posner RG, Geng D, Haymore S, Bogert J, Pecht I, Licht A et al. Trivalent antigens for degranulation of mast cells. Organic Letters. 2007 Aug 30;9(18):3551-3554. https://doi.org/10.1021/ol071175h
Posner, Richard G ; Geng, Dianliang ; Haymore, Seth ; Bogert, James ; Pecht, Israel ; Licht, Arieh ; Savage, Paul B. / Trivalent antigens for degranulation of mast cells. In: Organic Letters. 2007 ; Vol. 9, No. 18. pp. 3551-3554.
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