Abstract
Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3551-3554 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 9 |
| Issue number | 18 |
| DOIs | |
| State | Published - Aug 30 2007 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Cite this
Posner, R. G., Geng, D., Haymore, S., Bogert, J., Pecht, I., Licht, A., & Savage, P. B. (2007). Trivalent antigens for degranulation of mast cells. Organic Letters, 9(18), 3551-3554. https://doi.org/10.1021/ol071175h