Abstract
Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3551-3554 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 9 |
| Issue number | 18 |
| DOIs | |
| State | Published - Aug 30 2007 |
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ASJC Scopus subject areas
- Molecular Medicine
Cite this
Trivalent antigens for degranulation of mast cells. / Posner, Richard G; Geng, Dianliang; Haymore, Seth; Bogert, James; Pecht, Israel; Licht, Arieh; Savage, Paul B.
In: Organic Letters, Vol. 9, No. 18, 30.08.2007, p. 3551-3554.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trivalent antigens for degranulation of mast cells
AU - Posner, Richard G
AU - Geng, Dianliang
AU - Haymore, Seth
AU - Bogert, James
AU - Pecht, Israel
AU - Licht, Arieh
AU - Savage, Paul B.
PY - 2007/8/30
Y1 - 2007/8/30
N2 - Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.
AB - Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=34548542100&partnerID=8YFLogxK
U2 - 10.1021/ol071175h
DO - 10.1021/ol071175h
M3 - Article
VL - 9
SP - 3551
EP - 3554
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 18
ER -