Transmission of methicillin-resistant staphylococcus aureus infection through solid organ transplantation: Confirmation via whole genome sequencing

J. M. Wendt, D. Kaul, B. M. Limbago, M. Ramesh, S. Cohle, A. M. Denison, E. M. Driebe, J. K. Rasheed, S. R. Zaki, D. M. Blau, C. D. Paddock, L. K. McDougal, D. M. Engelthaler, Paul S Keim, C. C. Roe, H. Akselrod, M. J. Kuehnert, S. V. Basavaraju

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We describe two cases of donor-derived methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that developed after transplantation of organs from a common donor who died from acute MRSA endocarditis. Both recipients developed recurrent MRSA infection despite appropriate antibiotic therapy, and required prolonged hospitalization and hospital readmission. Comparison of S. aureus whole genome sequence of DNA extracted from fixed donor tissue and recipients' isolates confirmed donor-derived transmission. Current guidelines emphasize the risk posed by donors with bacteremia from multidrug-resistant organisms. This investigation suggests that, particularly in the setting of donor endocarditis, even a standard course of prophylactic antibiotics may not be sufficient to prevent donor-derived infection. This manuscript describes two cases of donor-derived methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, confirmed through comparison of S. aureus whole genome sequence of DNA extracted from fixed donor tissue and recipients' isolates, that developed after transplantation of organs from a common donor who died from acute MRSA endocarditis. Also see case report by Altman et al on page 2640.

Original languageEnglish (US)
Pages (from-to)2633-2639
Number of pages7
JournalAmerican Journal of Transplantation
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Fingerprint

Organ Transplantation
Methicillin-Resistant Staphylococcus aureus
Genome
Bacteremia
Endocarditis
Infection
Staphylococcus aureus
Tissue Donors
Anti-Bacterial Agents
Patient Readmission
Hospitalization
Guidelines

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Transmission of methicillin-resistant staphylococcus aureus infection through solid organ transplantation : Confirmation via whole genome sequencing. / Wendt, J. M.; Kaul, D.; Limbago, B. M.; Ramesh, M.; Cohle, S.; Denison, A. M.; Driebe, E. M.; Rasheed, J. K.; Zaki, S. R.; Blau, D. M.; Paddock, C. D.; McDougal, L. K.; Engelthaler, D. M.; Keim, Paul S; Roe, C. C.; Akselrod, H.; Kuehnert, M. J.; Basavaraju, S. V.

In: American Journal of Transplantation, Vol. 14, No. 11, 01.11.2014, p. 2633-2639.

Research output: Contribution to journalArticle

Wendt, JM, Kaul, D, Limbago, BM, Ramesh, M, Cohle, S, Denison, AM, Driebe, EM, Rasheed, JK, Zaki, SR, Blau, DM, Paddock, CD, McDougal, LK, Engelthaler, DM, Keim, PS, Roe, CC, Akselrod, H, Kuehnert, MJ & Basavaraju, SV 2014, 'Transmission of methicillin-resistant staphylococcus aureus infection through solid organ transplantation: Confirmation via whole genome sequencing', American Journal of Transplantation, vol. 14, no. 11, pp. 2633-2639. https://doi.org/10.1111/ajt.12898
Wendt, J. M. ; Kaul, D. ; Limbago, B. M. ; Ramesh, M. ; Cohle, S. ; Denison, A. M. ; Driebe, E. M. ; Rasheed, J. K. ; Zaki, S. R. ; Blau, D. M. ; Paddock, C. D. ; McDougal, L. K. ; Engelthaler, D. M. ; Keim, Paul S ; Roe, C. C. ; Akselrod, H. ; Kuehnert, M. J. ; Basavaraju, S. V. / Transmission of methicillin-resistant staphylococcus aureus infection through solid organ transplantation : Confirmation via whole genome sequencing. In: American Journal of Transplantation. 2014 ; Vol. 14, No. 11. pp. 2633-2639.
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