The salvage/turnover/repair (STOR) model for uniparental inheritance in Chlamydomonas

DNA as a source of sustenance

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The non-Mendetian inheritance of chloroplast genes in Chlamydomonas has engaged researchers for decades and has prompted numerous debates regarding molecular mechanisms and evolutionary significance. The hallmarks of chioroplast inheritance in Chlamydomonas are reviewed here, including observations on vegetative haploid cells, somatic hybrids, meiotic zygospores, and vegetative zygotes resulting from sexual reproduction. Models invoked to explain the typical uniparental maternal inheritance of chloroplast genes, and which center upon the presumed existence of sex-specific protectors and destroyers of chloroplast genomes, are briefly discussed. In an effort to bring together the diverse observations on chloroplast gene inheritance in somatic as well as sexual cells, a model is proposed that focuses on organelle DNA turnover as a source of sustenance for the cell during periods of starvation. The salvage/turnover/repair (STOR) model for chloroplast inheritance in Chlamydomonas proposes that as a consequence of the high ploidy of the chloroplast genome, many copies are dispensable; their degradation would provide nucleotides for recombination, repair, RNA synthesis and cell metabolism. The STOR model offers an alternative view of uniparental inheritance as a phenomenon of direct selective benefit to the organism rather than simply being of selfish benefit to the chloroplast genome. These concepts may also have application to other lower eukaryotes that have sexual reproduction coupled with an extended dormancy.

Original languageEnglish (US)
Pages (from-to)366-376
Number of pages11
JournalJournal of Heredity
Volume85
Issue number5
StatePublished - Sep 1994

Fingerprint

Chlamydomonas
Chloroplast Genes
Chloroplast Genome
Salvaging
Chloroplast
Repair
inheritance (genetics)
DNA
Genes
Reproduction
chloroplasts
Recombinational DNA Repair
Zygote
Ploidies
Haploidy
Chloroplasts
Genome
Starvation
Eukaryota
sexual reproduction

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Genetics(clinical)
  • Biotechnology
  • Molecular Biology
  • Genetics
  • Agricultural and Biological Sciences(all)

Cite this

The salvage/turnover/repair (STOR) model for uniparental inheritance in Chlamydomonas : DNA as a source of sustenance. / Sears, B. B.; VanWinkle-Swift, Karen P.

In: Journal of Heredity, Vol. 85, No. 5, 09.1994, p. 366-376.

Research output: Contribution to journalArticle

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