The role of chromium(V) in the mechanism of chromate-induced oxidative DNA damage and cancer

K. D. Sugden, Diane M Stearns

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

The role that high valent chromium intermediates play in the oxidative DNA damage produced by the human carcinogen chromate Cr(VI) is of increasing interest for establishing a mechanism of genotoxicity and mutagenicity for this metal. In this review, the authors summarize experimental evidence for the formation of high valent chromium complexes (primarily the +5 oxidation state) and radical species from the reductive metabolism of Cr(VI). A case is made for a direct- or metal-mediated pathway by high valent chromium to initiate oxidative DNA damage, although the role of radical species in this oxidative process cannot be ruled out.

Original languageEnglish (US)
Pages (from-to)215-230
Number of pages16
JournalJournal of Environmental Pathology, Toxicology and Oncology
Volume19
Issue number3
StatePublished - 2000
Externally publishedYes

Fingerprint

Chromates
chromate
Chromium
DNA Damage
chromium
cancer
DNA
damage
Metals
Neoplasms
mutagenicity
metal
genotoxicity
carcinogen
Metabolism
Carcinogens
metabolism
oxidation
Oxidation
chromium hexavalent ion

Keywords

  • Carcinogenesis
  • Chromium
  • Cr(V)
  • Mutagenesis
  • Oxidative DNA damage
  • Radicals

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

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AB - The role that high valent chromium intermediates play in the oxidative DNA damage produced by the human carcinogen chromate Cr(VI) is of increasing interest for establishing a mechanism of genotoxicity and mutagenicity for this metal. In this review, the authors summarize experimental evidence for the formation of high valent chromium complexes (primarily the +5 oxidation state) and radical species from the reductive metabolism of Cr(VI). A case is made for a direct- or metal-mediated pathway by high valent chromium to initiate oxidative DNA damage, although the role of radical species in this oxidative process cannot be ruled out.

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