The personal human oral microbiome obscures the effects of treatment on periodontal disease

Karen Schwarzberg, Rosalin Le, Balambal Bharti, Suzanne Lindsay, Giorgio Casaburi, Francesco Salvatore, Mohamed H. Saber, Faisal Alonaizan, Jørgen Slots, Roberta A. Gottlieb, James G Caporaso, Scott T. Kelley

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Periodontitis is a progressive disease of the periodontium with a complex, polymicrobial etiology. Recent Next-Generation Sequencing (NGS) studies of the microbial diversity associated with periodontitis have revealed strong, community-level differences in bacterial assemblages associated with healthy or diseased periodontal sites. In this study, we used NGS approaches to characterize changes in periodontal pocket bacterial diversity after standard periodontal treatment. Despite consistent changes in the abundance of certain taxa in individuals whose condition improved with treatment, post-treatment samples retained the highest similarity to pre-treatment samples from the same individual. Deeper phylogenetic analysis of periodontal pathogen-containing genera Prevotella and Fusobacterium found both unexpected diversity and differential treatment response among species. Our results highlight how understanding interpersonal variability among microbiomes is necessary for determining how polymicrobial diseases respond to treatment and disturbance.

Original languageEnglish (US)
Article numbere86708
JournalPLoS One
Volume9
Issue number1
DOIs
StatePublished - Jan 29 2014

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Periodontitis
Microbiota
Periodontal Diseases
mouth
Fusobacterium
Prevotella
Periodontal Pocket
Periodontium
Pathogens
etiology
pretreatment
sampling
pathogens
phylogeny
microbiome
periodontitis
periodontal diseases

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Schwarzberg, K., Le, R., Bharti, B., Lindsay, S., Casaburi, G., Salvatore, F., ... Kelley, S. T. (2014). The personal human oral microbiome obscures the effects of treatment on periodontal disease. PLoS One, 9(1), [e86708]. https://doi.org/10.1371/journal.pone.0086708

The personal human oral microbiome obscures the effects of treatment on periodontal disease. / Schwarzberg, Karen; Le, Rosalin; Bharti, Balambal; Lindsay, Suzanne; Casaburi, Giorgio; Salvatore, Francesco; Saber, Mohamed H.; Alonaizan, Faisal; Slots, Jørgen; Gottlieb, Roberta A.; Caporaso, James G; Kelley, Scott T.

In: PLoS One, Vol. 9, No. 1, e86708, 29.01.2014.

Research output: Contribution to journalArticle

Schwarzberg, K, Le, R, Bharti, B, Lindsay, S, Casaburi, G, Salvatore, F, Saber, MH, Alonaizan, F, Slots, J, Gottlieb, RA, Caporaso, JG & Kelley, ST 2014, 'The personal human oral microbiome obscures the effects of treatment on periodontal disease', PLoS One, vol. 9, no. 1, e86708. https://doi.org/10.1371/journal.pone.0086708
Schwarzberg K, Le R, Bharti B, Lindsay S, Casaburi G, Salvatore F et al. The personal human oral microbiome obscures the effects of treatment on periodontal disease. PLoS One. 2014 Jan 29;9(1). e86708. https://doi.org/10.1371/journal.pone.0086708
Schwarzberg, Karen ; Le, Rosalin ; Bharti, Balambal ; Lindsay, Suzanne ; Casaburi, Giorgio ; Salvatore, Francesco ; Saber, Mohamed H. ; Alonaizan, Faisal ; Slots, Jørgen ; Gottlieb, Roberta A. ; Caporaso, James G ; Kelley, Scott T. / The personal human oral microbiome obscures the effects of treatment on periodontal disease. In: PLoS One. 2014 ; Vol. 9, No. 1.
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