The impact of multiplex genetic testing on disease risk perceptions

S. Shiloh, Hendrik de Heer, S. Peleg, S. Hensley Alford, K. Skapinsky, J. S. Roberts, D. W. Hadley

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study assessed the effects of multiplex genetic testing on disease risk perceptions among 216 healthy adults. Participants, aged 25-40, were recruited through the Multiplex Initiative, which offered a genetic susceptibility test for eight common diseases. Participants completed baseline telephone and web-based surveys prior to making the testing decision. Three months after the receipt of mailed test results, participants completed a follow-up telephone survey. Risk perceptions for the eight diseases were measured at baseline and follow-up, along with beliefs about genetic causation of those diseases. The main results were: (i) mean risk perceptions were considerably stable from baseline to follow-up; (ii) the best predictors of follow-up risk perceptions were the corresponding baseline perceptions and family history; and (iii) within-individuals, most participants increased or decreased their risk perceptions for specific diseases in concordance with the number of risk markers they carry, their family history and their beliefs about genetic causality of diseases. In conclusion, participants presented a vigilant approach to the interpretation of genetic test results, which provides reassurance with regard to a potential inflation of risk perceptions in the population because of multiplex genetic testing. Section Editor: Aad Tibben, email: a.tibben@lumc.nl

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalClinical Genetics
Volume87
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Genetic Testing
Telephone
Causality
Inborn Genetic Diseases
Economic Inflation
Genetic Predisposition to Disease
Decision Making
Population

Keywords

  • Family history
  • Genetic testing
  • Multiplex
  • Risk perception

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Medicine(all)

Cite this

Shiloh, S., de Heer, H., Peleg, S., Hensley Alford, S., Skapinsky, K., Roberts, J. S., & Hadley, D. W. (2015). The impact of multiplex genetic testing on disease risk perceptions. Clinical Genetics, 87(2), 117-123. https://doi.org/10.1111/cge.12403

The impact of multiplex genetic testing on disease risk perceptions. / Shiloh, S.; de Heer, Hendrik; Peleg, S.; Hensley Alford, S.; Skapinsky, K.; Roberts, J. S.; Hadley, D. W.

In: Clinical Genetics, Vol. 87, No. 2, 01.02.2015, p. 117-123.

Research output: Contribution to journalArticle

Shiloh, S, de Heer, H, Peleg, S, Hensley Alford, S, Skapinsky, K, Roberts, JS & Hadley, DW 2015, 'The impact of multiplex genetic testing on disease risk perceptions', Clinical Genetics, vol. 87, no. 2, pp. 117-123. https://doi.org/10.1111/cge.12403
Shiloh S, de Heer H, Peleg S, Hensley Alford S, Skapinsky K, Roberts JS et al. The impact of multiplex genetic testing on disease risk perceptions. Clinical Genetics. 2015 Feb 1;87(2):117-123. https://doi.org/10.1111/cge.12403
Shiloh, S. ; de Heer, Hendrik ; Peleg, S. ; Hensley Alford, S. ; Skapinsky, K. ; Roberts, J. S. ; Hadley, D. W. / The impact of multiplex genetic testing on disease risk perceptions. In: Clinical Genetics. 2015 ; Vol. 87, No. 2. pp. 117-123.
@article{869d1efc005e4a048d7898f824e25c8b,
title = "The impact of multiplex genetic testing on disease risk perceptions",
abstract = "This study assessed the effects of multiplex genetic testing on disease risk perceptions among 216 healthy adults. Participants, aged 25-40, were recruited through the Multiplex Initiative, which offered a genetic susceptibility test for eight common diseases. Participants completed baseline telephone and web-based surveys prior to making the testing decision. Three months after the receipt of mailed test results, participants completed a follow-up telephone survey. Risk perceptions for the eight diseases were measured at baseline and follow-up, along with beliefs about genetic causation of those diseases. The main results were: (i) mean risk perceptions were considerably stable from baseline to follow-up; (ii) the best predictors of follow-up risk perceptions were the corresponding baseline perceptions and family history; and (iii) within-individuals, most participants increased or decreased their risk perceptions for specific diseases in concordance with the number of risk markers they carry, their family history and their beliefs about genetic causality of diseases. In conclusion, participants presented a vigilant approach to the interpretation of genetic test results, which provides reassurance with regard to a potential inflation of risk perceptions in the population because of multiplex genetic testing. Section Editor: Aad Tibben, email: a.tibben@lumc.nl",
keywords = "Family history, Genetic testing, Multiplex, Risk perception",
author = "S. Shiloh and {de Heer}, Hendrik and S. Peleg and {Hensley Alford}, S. and K. Skapinsky and Roberts, {J. S.} and Hadley, {D. W.}",
year = "2015",
month = "2",
day = "1",
doi = "10.1111/cge.12403",
language = "English (US)",
volume = "87",
pages = "117--123",
journal = "Clinical Genetics",
issn = "0009-9163",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - The impact of multiplex genetic testing on disease risk perceptions

AU - Shiloh, S.

AU - de Heer, Hendrik

AU - Peleg, S.

AU - Hensley Alford, S.

AU - Skapinsky, K.

AU - Roberts, J. S.

AU - Hadley, D. W.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - This study assessed the effects of multiplex genetic testing on disease risk perceptions among 216 healthy adults. Participants, aged 25-40, were recruited through the Multiplex Initiative, which offered a genetic susceptibility test for eight common diseases. Participants completed baseline telephone and web-based surveys prior to making the testing decision. Three months after the receipt of mailed test results, participants completed a follow-up telephone survey. Risk perceptions for the eight diseases were measured at baseline and follow-up, along with beliefs about genetic causation of those diseases. The main results were: (i) mean risk perceptions were considerably stable from baseline to follow-up; (ii) the best predictors of follow-up risk perceptions were the corresponding baseline perceptions and family history; and (iii) within-individuals, most participants increased or decreased their risk perceptions for specific diseases in concordance with the number of risk markers they carry, their family history and their beliefs about genetic causality of diseases. In conclusion, participants presented a vigilant approach to the interpretation of genetic test results, which provides reassurance with regard to a potential inflation of risk perceptions in the population because of multiplex genetic testing. Section Editor: Aad Tibben, email: a.tibben@lumc.nl

AB - This study assessed the effects of multiplex genetic testing on disease risk perceptions among 216 healthy adults. Participants, aged 25-40, were recruited through the Multiplex Initiative, which offered a genetic susceptibility test for eight common diseases. Participants completed baseline telephone and web-based surveys prior to making the testing decision. Three months after the receipt of mailed test results, participants completed a follow-up telephone survey. Risk perceptions for the eight diseases were measured at baseline and follow-up, along with beliefs about genetic causation of those diseases. The main results were: (i) mean risk perceptions were considerably stable from baseline to follow-up; (ii) the best predictors of follow-up risk perceptions were the corresponding baseline perceptions and family history; and (iii) within-individuals, most participants increased or decreased their risk perceptions for specific diseases in concordance with the number of risk markers they carry, their family history and their beliefs about genetic causality of diseases. In conclusion, participants presented a vigilant approach to the interpretation of genetic test results, which provides reassurance with regard to a potential inflation of risk perceptions in the population because of multiplex genetic testing. Section Editor: Aad Tibben, email: a.tibben@lumc.nl

KW - Family history

KW - Genetic testing

KW - Multiplex

KW - Risk perception

UR - http://www.scopus.com/inward/record.url?scp=84921438012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921438012&partnerID=8YFLogxK

U2 - 10.1111/cge.12403

DO - 10.1111/cge.12403

M3 - Article

VL - 87

SP - 117

EP - 123

JO - Clinical Genetics

JF - Clinical Genetics

SN - 0009-9163

IS - 2

ER -