The effect of nicotine on glycogen synthesis

K. Rosen, S. Fontaine, H. Chowaniec, L. Burdjck, Cynthia J Hartzell, H. Gunderson

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to determine the effect of nicotine on glycogen synthesis. Following a 24 hour fast, female Sprague-Dawley rats were infused for 2 hours at 9-5 ul/rnin with 25% [1-13C] glucose. In addition, the infusate contained 1.1 rnM nicotine bitartrate for the nicotine treated animals(N) and no nicotine for the control group(C). After the infusion, the animal was anes(hetized, liver tissue was removed, freeze clamped and stored at -85C. NMR spectra indicate the glycogen was synthesized using a greater amount of direct pathway in N compared to C (52% vs 29%, P-0.012). Liver glycogen concentration was 23.2 mg/g for C and 10.8 mg/g for N (P<0.001). The effect of nicotine was to increase the use of the direct pathway, but decrease the amount of net glycogen synthesis. Results indicate that the natural pathway of glucose is modified by nicotine in such a way as to more directly convert it to glycogen before allowing it to be used by peripheral tissues.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number8
StatePublished - 1998

Fingerprint

nicotine
Glycogen
Nicotine
glycogen
synthesis
Animals
Tissue
Glucose
liver
Liver Glycogen
glucose
Liver
Sprague Dawley Rats
Rats
animals
Nuclear magnetic resonance
Control Groups
rats

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Rosen, K., Fontaine, S., Chowaniec, H., Burdjck, L., Hartzell, C. J., & Gunderson, H. (1998). The effect of nicotine on glycogen synthesis. FASEB Journal, 12(8).

The effect of nicotine on glycogen synthesis. / Rosen, K.; Fontaine, S.; Chowaniec, H.; Burdjck, L.; Hartzell, Cynthia J; Gunderson, H.

In: FASEB Journal, Vol. 12, No. 8, 1998.

Research output: Contribution to journalArticle

Rosen, K, Fontaine, S, Chowaniec, H, Burdjck, L, Hartzell, CJ & Gunderson, H 1998, 'The effect of nicotine on glycogen synthesis', FASEB Journal, vol. 12, no. 8.
Rosen K, Fontaine S, Chowaniec H, Burdjck L, Hartzell CJ, Gunderson H. The effect of nicotine on glycogen synthesis. FASEB Journal. 1998;12(8).
Rosen, K. ; Fontaine, S. ; Chowaniec, H. ; Burdjck, L. ; Hartzell, Cynthia J ; Gunderson, H. / The effect of nicotine on glycogen synthesis. In: FASEB Journal. 1998 ; Vol. 12, No. 8.
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