Synthesis of 2-C-Methyl-D-erythritol 4-phosphate: The first pathway-specific intermediate in the methylerythritol phosphate route to isoprenoids

Andrew T. Koppisch, Brian S.J. Blagg, C. Dale Poulter

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

(matrix presented) 2-C-Methyl-D-erythritol 4-phosphate (4), formed from 1-deoxy-D-xylulose 5-phosphate (3), is the first pathway-specific intermediate in the methylerythritol phosphate route for the biosynthesis of isoprenoid compounds in bacteria, algae, and plant chloroplasts. In this report, 4 was synthesized from 1,2-propanediol (7) in seven steps with an overall yield of 32% and in an enantiomeric excess of 78%.

Original languageEnglish (US)
Pages (from-to)215-217
Number of pages3
JournalOrganic Letters
Volume2
Issue number2
DOIs
StatePublished - Jan 27 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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