Sympathetic activation during early pregnancy in humans

Sara S. Jarvis, Shigeki Shibata, Tiffany B. Bivens, Yoshiyuki Okada, Brian M. Casey, Benjamin D. Levine, Qi Fu

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

• Sympathetic activity has been reported to increase in normotensive pregnant women, and to be even greater in women with gestational hypertension and preeclampsia at term. • Whether sympathetic overactivity develops early during pregnancy, remaining high throughout gestation, or whether it only occurs at term providing the substrate for hypertensive disorders is unknown. • We found that vasomotor sympathetic activity was markedly greater, diastolic pressure trended lower, total peripheral resistance decreased, sympathetic vascular transduction was blunted, and renin and aldosterone both were higher during early pregnancy (i.e. ≤8 weeks of gestation) than pre-pregnancy. • It is suggested that sympathetic activation is a common characteristic of early pregnancy in normotensive women. • These results help us better understand blood pressure control mechanisms during normal pregnancy in humans. Sympathetic activity has been reported to increase in normotensive pregnant women, and to be even greater in women with gestational hypertension and preeclampsia at term. Whether sympathetic overactivity develops early during pregnancy, remaining high throughout gestation, or whether it only occurs at term providing the substrate for hypertensive disorders is unknown. We tested the hypothesis that sympathetic activation occurs early during pregnancy in humans. Eleven healthy women (29 ± 3 (SD) years) without prior hypertensive pregnancies were tested during the mid-luteal phase (PRE) and early pregnancy (EARLY; 6.2 ± 1.2 weeks of gestation). Muscle sympathetic nerve activity (MSNA) and haemodynamics were measured supine, at 30 deg and 60 deg upright tilt for 5 min each. Blood samples were drawn for catecholamines, direct renin, and aldosterone. MSNA was significantly greater during EARLY than PRE (supine: 25 ± 8 vs. 14 ± 8 bursts min -1, 60 deg tilt: 49 ± 14 vs. 40 ± 10 bursts min -1; main effect, P < 0.05). Resting diastolic pressure trended lower (P= 0.09), heart rate was similar, total peripheral resistance decreased (2172 ± 364 vs. 2543 ± 352 dyne s cm -5; P < 0.05), sympathetic vascular transduction was blunted (0.10 ± 0.05 vs. 0.36 ± 0.47 units a.u. -1 min -1; P < 0.01), and both renin (supine: 27.9 ± 6.2 vs. 14.2 ± 8.7 pg ml -1, P < 0.01) and aldosterone (supine: 16.7 ± 14.1 vs. 7.7 ± 6.8 ng ml -1, P= 0.05) were higher during EARLY than PRE. These results suggest that sympathetic activation is a common characteristic of early pregnancy in humans despite reduced diastolic pressure and total peripheral resistance. These observations challenge conventional thinking about blood pressure regulation during pregnancy, showing marked sympathetic activation occurring within the first few weeks of conception, and may provide the substrate for pregnancy induced cardiovascular complications.

Original languageEnglish (US)
Pages (from-to)3535-3543
Number of pages9
JournalJournal of Physiology
Volume590
Issue number15
DOIs
StatePublished - Aug 2012

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Pregnancy
Blood Pressure
Aldosterone
Renin
Vascular Resistance
Pregnancy Induced Hypertension
Pre-Eclampsia
Cardiovascular Pregnancy Complications
Blood Vessels
Pregnant Women
Muscles
Luteal Phase
Catecholamines
Heart Rate
Hemodynamics

ASJC Scopus subject areas

  • Physiology

Cite this

Jarvis, S. S., Shibata, S., Bivens, T. B., Okada, Y., Casey, B. M., Levine, B. D., & Fu, Q. (2012). Sympathetic activation during early pregnancy in humans. Journal of Physiology, 590(15), 3535-3543. https://doi.org/10.1113/jphysiol.2012.228262

Sympathetic activation during early pregnancy in humans. / Jarvis, Sara S.; Shibata, Shigeki; Bivens, Tiffany B.; Okada, Yoshiyuki; Casey, Brian M.; Levine, Benjamin D.; Fu, Qi.

In: Journal of Physiology, Vol. 590, No. 15, 08.2012, p. 3535-3543.

Research output: Contribution to journalArticle

Jarvis, SS, Shibata, S, Bivens, TB, Okada, Y, Casey, BM, Levine, BD & Fu, Q 2012, 'Sympathetic activation during early pregnancy in humans', Journal of Physiology, vol. 590, no. 15, pp. 3535-3543. https://doi.org/10.1113/jphysiol.2012.228262
Jarvis SS, Shibata S, Bivens TB, Okada Y, Casey BM, Levine BD et al. Sympathetic activation during early pregnancy in humans. Journal of Physiology. 2012 Aug;590(15):3535-3543. https://doi.org/10.1113/jphysiol.2012.228262
Jarvis, Sara S. ; Shibata, Shigeki ; Bivens, Tiffany B. ; Okada, Yoshiyuki ; Casey, Brian M. ; Levine, Benjamin D. ; Fu, Qi. / Sympathetic activation during early pregnancy in humans. In: Journal of Physiology. 2012 ; Vol. 590, No. 15. pp. 3535-3543.
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