Staphylococcus aureus and the ecology of the nasal microbiome

Cindy M. Liu, Lance B. Price, Bruce A Hungate, Alison G. Abraham, Lisbeth A. Larsen, Kaare Christensen, Marc Stegger, Robert Skov, Paal Skytt Andersen

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.

Original languageEnglish (US)
Article numbere1400216
JournalScience advances
Volume1
Issue number5
DOIs
StatePublished - Jun 1 2015

Fingerprint

Microbiota
Ecology
Nose
Staphylococcus aureus
Bacteria
Dizygotic Twins
Nasal Cavity
Lactic Acid

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liu, C. M., Price, L. B., Hungate, B. A., Abraham, A. G., Larsen, L. A., Christensen, K., ... Andersen, P. S. (2015). Staphylococcus aureus and the ecology of the nasal microbiome. Science advances, 1(5), [e1400216]. https://doi.org/10.1126/sciadv.1400216

Staphylococcus aureus and the ecology of the nasal microbiome. / Liu, Cindy M.; Price, Lance B.; Hungate, Bruce A; Abraham, Alison G.; Larsen, Lisbeth A.; Christensen, Kaare; Stegger, Marc; Skov, Robert; Andersen, Paal Skytt.

In: Science advances, Vol. 1, No. 5, e1400216, 01.06.2015.

Research output: Contribution to journalArticle

Liu, CM, Price, LB, Hungate, BA, Abraham, AG, Larsen, LA, Christensen, K, Stegger, M, Skov, R & Andersen, PS 2015, 'Staphylococcus aureus and the ecology of the nasal microbiome', Science advances, vol. 1, no. 5, e1400216. https://doi.org/10.1126/sciadv.1400216
Liu CM, Price LB, Hungate BA, Abraham AG, Larsen LA, Christensen K et al. Staphylococcus aureus and the ecology of the nasal microbiome. Science advances. 2015 Jun 1;1(5). e1400216. https://doi.org/10.1126/sciadv.1400216
Liu, Cindy M. ; Price, Lance B. ; Hungate, Bruce A ; Abraham, Alison G. ; Larsen, Lisbeth A. ; Christensen, Kaare ; Stegger, Marc ; Skov, Robert ; Andersen, Paal Skytt. / Staphylococcus aureus and the ecology of the nasal microbiome. In: Science advances. 2015 ; Vol. 1, No. 5.
@article{c3df6a9248b74fe9a53fd156a9ba7b93,
title = "Staphylococcus aureus and the ecology of the nasal microbiome",
abstract = "The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.",
author = "Liu, {Cindy M.} and Price, {Lance B.} and Hungate, {Bruce A} and Abraham, {Alison G.} and Larsen, {Lisbeth A.} and Kaare Christensen and Marc Stegger and Robert Skov and Andersen, {Paal Skytt}",
year = "2015",
month = "6",
day = "1",
doi = "10.1126/sciadv.1400216",
language = "English (US)",
volume = "1",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "5",

}

TY - JOUR

T1 - Staphylococcus aureus and the ecology of the nasal microbiome

AU - Liu, Cindy M.

AU - Price, Lance B.

AU - Hungate, Bruce A

AU - Abraham, Alison G.

AU - Larsen, Lisbeth A.

AU - Christensen, Kaare

AU - Stegger, Marc

AU - Skov, Robert

AU - Andersen, Paal Skytt

PY - 2015/6/1

Y1 - 2015/6/1

N2 - The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.

AB - The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.

UR - http://www.scopus.com/inward/record.url?scp=84948671021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948671021&partnerID=8YFLogxK

U2 - 10.1126/sciadv.1400216

DO - 10.1126/sciadv.1400216

M3 - Article

AN - SCOPUS:84948671021

VL - 1

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 5

M1 - e1400216

ER -