Simulation of a computational winding filament model with an exponential spring to represent titin

Robert Lemoyne, Jeremy Petak, John Tester, Kiisa C Nishikawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The goal of developing high fidelity simulation of muscle force is of considerable interest for the biomedical community. Traditionally Hill models have been incorporated. However, feasible scope of the Hill model is inherently limited, especially in light of the growing relevance of muscle history dependence. History dependence is considered to be significant for motor control and stability. Attempts have been made to augment the Hill model to emulate history dependence. The titin winding filament model best elucidates history dependence of muscle force including force enhancement. The recent version of the titin winding filament model accounts for the functionality of titin through a pulley linked with the contractile element and a linear spring to represent the elastic properties of titin. A new and more realistic amendment to the winding filament model is incorporation of an exponential spring to characterize the elastic properties of titin. A sensitivity study as a function of the titin exponential spring constant is presented. Overall the amalgamation of the titin exponential spring to the winding filament model improves the respective force enhancement characteristics with a relatively more optimal exponential spring constant that provides a maximal averaged coefficient of determination.

Original languageEnglish (US)
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages836-839
Number of pages4
ISBN (Print)9781424479290
DOIs
StatePublished - Nov 2 2014
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
Duration: Aug 26 2014Aug 30 2014

Other

Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
CountryUnited States
CityChicago
Period8/26/148/30/14

Fingerprint

Connectin
Filament winding
History
Muscle
Muscles
Pulleys

Keywords

  • Hill model
  • muscle history dependence
  • muscle modeling
  • titin
  • winding filament hypothesis

ASJC Scopus subject areas

  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering

Cite this

Lemoyne, R., Petak, J., Tester, J., & Nishikawa, K. C. (2014). Simulation of a computational winding filament model with an exponential spring to represent titin. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 836-839). [6943721] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6943721

Simulation of a computational winding filament model with an exponential spring to represent titin. / Lemoyne, Robert; Petak, Jeremy; Tester, John; Nishikawa, Kiisa C.

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 836-839 6943721.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lemoyne, R, Petak, J, Tester, J & Nishikawa, KC 2014, Simulation of a computational winding filament model with an exponential spring to represent titin. in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014., 6943721, Institute of Electrical and Electronics Engineers Inc., pp. 836-839, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Chicago, United States, 8/26/14. https://doi.org/10.1109/EMBC.2014.6943721
Lemoyne R, Petak J, Tester J, Nishikawa KC. Simulation of a computational winding filament model with an exponential spring to represent titin. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc. 2014. p. 836-839. 6943721 https://doi.org/10.1109/EMBC.2014.6943721
Lemoyne, Robert ; Petak, Jeremy ; Tester, John ; Nishikawa, Kiisa C. / Simulation of a computational winding filament model with an exponential spring to represent titin. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 836-839
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