Sensitivity of avian intrapulmonary chemoreceptors to venous CO2 load

Steven C. Hempleman, Thomas P. Adamson, Ray E. Burger

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

To investigate the response of individula intrapulmonary chemoreceptors (IPC) to venous CO2 loads approximating moderate muscular exercise, we recorded vagal discharege from 33 IPC arising frmo the left lungs of 9 anesthetized, unidirectionally ventilated Pekin ducks. Each IPC was studied during control conditions (PeCO2 = 29.0 ± 0.8 Torr, PvCO2 = 30.2 ± 0.6 Torr) and during venous CO2 load (PeCO2 = 29.5 ± 0.7 Torr, PvCO2 = 51.5 ± 1.4 Torr). Venous loading was produced by increasing the percentate of CO2 in the gas ventilating the right lung form 0 to 9-25% CO2. The flow of 1% CO2 through the left lung was adjusted to keep the left lung PECO2 constant. During venous loading, discharge frequenceis indicated that the PCO2 at the receptive sites fell, on teh averaga, 1.6 ± 0.8 Torr.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalRespiration Physiology
Volume66
Issue number1
DOIs
StatePublished - Oct 1986
Externally publishedYes

Keywords

  • Duck
  • Exercise
  • Lung chemoreceptors
  • Mixed venous blood
  • Respiratory control
  • Ventilatory inhibition

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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