Scaling mitochondrial volume in heart to body mass

Hans Hoppeler, Stan L. Lindstedt, Helgard Claassen, C. Richard Taylor, Odile Mathieu, Ewald R. Weibel

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The heart mass was measured and the volume density of mitochondria, Vv(mt,f), morphometrically estimated in 11 mammalian species ranging from shrew (3 g) to cattle (920 kg). The mass or the volume of the heart muscle (Vh) was found to scale as Mb0.970 whereas Vv(mt,f) scaled as Mb-0.044. Hence, the total volume of mitochondria in heart, V(mt), scaled as Mb0.927 (V(mt)= VV(mt,f) × Vh). The volume of heart mitochondria was found to scale disproportionately to V̇O2 max (Mb0.75) but in proportion to resting cardiac work rate (Mb0.9).

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalRespiration Physiology
Volume55
Issue number2
DOIs
StatePublished - Feb 1984
Externally publishedYes

Keywords

  • Allometric relation
  • Cardiac muscle
  • Cat
  • Cattle
  • Coyote
  • Dog
  • Fox
  • Heart mass
  • Heart size
  • Horse
  • Maximal oxygen consumption
  • Mitochondrion
  • Myocardium
  • Rat
  • Shrew
  • Skeletal muscle
  • Wolf
  • Woodmouse

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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  • Cite this

    Hoppeler, H., Lindstedt, S. L., Claassen, H., Taylor, C. R., Mathieu, O., & Weibel, E. R. (1984). Scaling mitochondrial volume in heart to body mass. Respiration Physiology, 55(2), 131-137. https://doi.org/10.1016/0034-5687(84)90018-5