Abstract
Three selection experiments were used to identify chromosome regions that contain QTL affecting late-life and early-life fitness in Drosophila melanogaster. The selection experiments were initiated by crossing pairs of inbred lines that had been derived from outbred laboratory populations that had different mean life spans. QTL regions were located by association with microsatellite markers that showed significant selection responses. Regions between recombination map positions 54 and 81 on chromosome 2, between 0 and 30 on chromosome 3, and near locations 49 and 81 on chromosome 3 had the strongest support as locations of life-span QTL. There was good general agreement between the life-span QTL regions that were identified by selection and those that were identified in a companion recombination mapping experiment that used the same fly stocks. Many marker loci responded in opposite directions to selection for late- and early-life fitness, indicating negative genetic correlations or trade-offs between those traits. Indirect evidence suggested that some negative genetic correlations were due to antagonistic pleiotropy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 313-324 |
| Number of pages | 12 |
| Journal | Genetics |
| Volume | 168 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 2004 |
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ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
Cite this
Quantitative trait loci affecting life span in replicated populations of Drosophila melanogaster. II. Response to selection. / Valenzuela, Robert K.; Forbes, Scott N.; Keim, Paul S; Service, Philip M.
In: Genetics, Vol. 168, No. 1, 09.2004, p. 313-324.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitative trait loci affecting life span in replicated populations of Drosophila melanogaster. II. Response to selection
AU - Valenzuela, Robert K.
AU - Forbes, Scott N.
AU - Keim, Paul S
AU - Service, Philip M.
PY - 2004/9
Y1 - 2004/9
N2 - Three selection experiments were used to identify chromosome regions that contain QTL affecting late-life and early-life fitness in Drosophila melanogaster. The selection experiments were initiated by crossing pairs of inbred lines that had been derived from outbred laboratory populations that had different mean life spans. QTL regions were located by association with microsatellite markers that showed significant selection responses. Regions between recombination map positions 54 and 81 on chromosome 2, between 0 and 30 on chromosome 3, and near locations 49 and 81 on chromosome 3 had the strongest support as locations of life-span QTL. There was good general agreement between the life-span QTL regions that were identified by selection and those that were identified in a companion recombination mapping experiment that used the same fly stocks. Many marker loci responded in opposite directions to selection for late- and early-life fitness, indicating negative genetic correlations or trade-offs between those traits. Indirect evidence suggested that some negative genetic correlations were due to antagonistic pleiotropy.
AB - Three selection experiments were used to identify chromosome regions that contain QTL affecting late-life and early-life fitness in Drosophila melanogaster. The selection experiments were initiated by crossing pairs of inbred lines that had been derived from outbred laboratory populations that had different mean life spans. QTL regions were located by association with microsatellite markers that showed significant selection responses. Regions between recombination map positions 54 and 81 on chromosome 2, between 0 and 30 on chromosome 3, and near locations 49 and 81 on chromosome 3 had the strongest support as locations of life-span QTL. There was good general agreement between the life-span QTL regions that were identified by selection and those that were identified in a companion recombination mapping experiment that used the same fly stocks. Many marker loci responded in opposite directions to selection for late- and early-life fitness, indicating negative genetic correlations or trade-offs between those traits. Indirect evidence suggested that some negative genetic correlations were due to antagonistic pleiotropy.
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U2 - 10.1534/genetics.103.023291
DO - 10.1534/genetics.103.023291
M3 - Article
VL - 168
SP - 313
EP - 324
JO - Genetics
JF - Genetics
SN - 0016-6731
IS - 1
ER -