Q fever epidemic in Hungary, April to July 2013

M. Gyuranecz, K. M. Sulyok, E. Balla, T. Mag, A. Balázs, Z. Simor, B. Dénes, S. Hornok, P. Bajnóczi, H. M. Hornstra, Talima R Pearson, Paul S Keim, A. Dán

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We investigated a Q fever outbreak with human patients showing high fever, respiratory tract symptoms, headache and retrosternal pain in southern Hungary in the spring and summer of 2013. Seventy human cases were confirmed by analysing their serum and blood samples with micro-immunofluorescence test and real-time PCR. The source of infection was a merino sheep flock of 450 ewes, in which 44.6% (25/56) seropositivity was detected by enzyme-linked immunosorbent assay. Coxiella burnetii DNA was detected by real-time PCR in the milk of four of 20 individuals and in two thirds (41/65) of the manure samples. The multispacer sequence typing examination of C. burnetii DNA revealed sequence type 18 in one human sample and two manure samples from the sheep flock. The multilocus variable-number tandem repeat analysis pattern of the sheep and human strains were also almost identical, 4/5-9-3-3-0-5 (Ms23-Ms24-Ms27-Ms28-Ms33-Ms34). It is hypothesised that dried manure and maternal fluid contaminated with C. burnetii was dispersed by the wind from the sheep farm towards the local inhabitants. The manure was eliminated in June and the farm was disinfected in July. The outbreak ended at the end of July 2013.

Original languageEnglish (US)
Article number20863
JournalEuro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin
Volume19
Issue number30
StatePublished - 2015

Fingerprint

Q Fever
Manure
Hungary
Coxiella burnetii
Sheep
Disease Outbreaks
Real-Time Polymerase Chain Reaction
Minisatellite Repeats
Respiratory System
Fluorescent Antibody Technique
Headache
Milk
Fever
Enzyme-Linked Immunosorbent Assay
Mothers
Pain
DNA
Infection
Serum
Farms

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Virology

Cite this

Gyuranecz, M., Sulyok, K. M., Balla, E., Mag, T., Balázs, A., Simor, Z., ... Dán, A. (2015). Q fever epidemic in Hungary, April to July 2013. Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin, 19(30), [20863].

Q fever epidemic in Hungary, April to July 2013. / Gyuranecz, M.; Sulyok, K. M.; Balla, E.; Mag, T.; Balázs, A.; Simor, Z.; Dénes, B.; Hornok, S.; Bajnóczi, P.; Hornstra, H. M.; Pearson, Talima R; Keim, Paul S; Dán, A.

In: Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin, Vol. 19, No. 30, 20863, 2015.

Research output: Contribution to journalArticle

Gyuranecz, M, Sulyok, KM, Balla, E, Mag, T, Balázs, A, Simor, Z, Dénes, B, Hornok, S, Bajnóczi, P, Hornstra, HM, Pearson, TR, Keim, PS & Dán, A 2015, 'Q fever epidemic in Hungary, April to July 2013', Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin, vol. 19, no. 30, 20863.
Gyuranecz, M. ; Sulyok, K. M. ; Balla, E. ; Mag, T. ; Balázs, A. ; Simor, Z. ; Dénes, B. ; Hornok, S. ; Bajnóczi, P. ; Hornstra, H. M. ; Pearson, Talima R ; Keim, Paul S ; Dán, A. / Q fever epidemic in Hungary, April to July 2013. In: Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin. 2015 ; Vol. 19, No. 30.
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