Pulmonary transit time and diffusing capacity in mammals.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Allometry is used as a tool to explain the apparent mismatch of oxygen consumption and diffusing capacity in the mammalian lung. By combining equations for pulmonary capillary volume and cardiac output, it is apparent that erythrocyte transit time through the lung must scale disproportionately to body mass. This inequality is a consequence of physical and mechanical properties setting optimal cardiac and respiratory frequencies. Because of much shorter transit times, the mean alveolar-capillary oxygen pressure difference increases as body size decreases. The time course of oxygen binding to hemoglobin may limit maximum oxygen consumption in the smallest mammals. To assure carbon dioxide diffusion equilibrium, levels of carbonic anhydrase are much higher in small than in large mammals. Because of the differences in transit time, the pulmonary diffusing capacity must scale linearly to body mass to assure adequate oxygen delivery in all mammals.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume246
Issue number3 Pt 2
StatePublished - Mar 1984
Externally publishedYes

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Mammals
Lung
Oxygen
Oxygen Consumption
Pulmonary Diffusing Capacity
Carbonic Anhydrases
Body Size
Carbon Dioxide
Cardiac Output
Hemoglobins
Erythrocytes
Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pulmonary transit time and diffusing capacity in mammals. / Lindstedt, Stan L.

In: The American journal of physiology, Vol. 246, No. 3 Pt 2, 03.1984.

Research output: Contribution to journalArticle

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