Possible differential host tropism in Anaplasma phagocytophilum strains in the western United States

Janet Foley, Nathan C Nieto, John Madigan, Jane Sykes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

27 Citations (Scopus)

Abstract

Despite organization into a single species, Anaplasma phagocytophilum, of bacteria from diverse hosts, there is evidence that different hosts vary in susceptibility to local strains of this bacterial pathogen. In particular, there is evidence that clinical hosts (humans, horses, and dogs) in the western part of the United States may be infected with strains of bacteria that differ from those in the reported wildlife reservoir, the dusky-footed woodrat. There is a lack of spatial overlap between clinical cases with woodrat exposure, genetic studies show highly distinctive strains in woodrats compared with those from clinical hosts, and experimental studies failed to transfer infection from woodrats into horses. These data suggest that multiple distinct A. phagocytophilum strains could circulate in western U.S. ecosystems. Host barriers to different bacterial strains would suggest the need for careful discrimination of A. phagocytophilum strains and further research to understand the host-pathogen interactions that result in differential outcomes in infection.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages94-97
Number of pages4
Volume1149
DOIs
StatePublished - Dec 2008
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1149
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Viral Tropism
Anaplasma phagocytophilum
Horses
Bacteria
Host-Pathogen Interactions
Pathogens
Infection
Ecosystem
Dogs
Research
Ecosystems

Keywords

  • Genospecies
  • Granulocytic anaplasmosis
  • Reservoir
  • Rodents

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Foley, J., Nieto, N. C., Madigan, J., & Sykes, J. (2008). Possible differential host tropism in Anaplasma phagocytophilum strains in the western United States. In Annals of the New York Academy of Sciences (Vol. 1149, pp. 94-97). (Annals of the New York Academy of Sciences; Vol. 1149). https://doi.org/10.1196/annals.1428.066

Possible differential host tropism in Anaplasma phagocytophilum strains in the western United States. / Foley, Janet; Nieto, Nathan C; Madigan, John; Sykes, Jane.

Annals of the New York Academy of Sciences. Vol. 1149 2008. p. 94-97 (Annals of the New York Academy of Sciences; Vol. 1149).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Foley, J, Nieto, NC, Madigan, J & Sykes, J 2008, Possible differential host tropism in Anaplasma phagocytophilum strains in the western United States. in Annals of the New York Academy of Sciences. vol. 1149, Annals of the New York Academy of Sciences, vol. 1149, pp. 94-97. https://doi.org/10.1196/annals.1428.066
Foley J, Nieto NC, Madigan J, Sykes J. Possible differential host tropism in Anaplasma phagocytophilum strains in the western United States. In Annals of the New York Academy of Sciences. Vol. 1149. 2008. p. 94-97. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1428.066
Foley, Janet ; Nieto, Nathan C ; Madigan, John ; Sykes, Jane. / Possible differential host tropism in Anaplasma phagocytophilum strains in the western United States. Annals of the New York Academy of Sciences. Vol. 1149 2008. pp. 94-97 (Annals of the New York Academy of Sciences).
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