Population structure and genetic diversity among isolates of coccidioides posadasii in Venezuela and surrounding regions

Marcus M. Teixeira, Primavera Alvarado, Chandler C. Roe, George R. Thompson, José S.L. Patané, Jason W. Sahl, Paul Keim, John N. Galgiani, Anastasia P. Litvintseva, Daniel R. Matute, Bridget M. Barker

Research output: Contribution to journalArticle

Abstract

Coccidioides posadasii is a pathogenic fungus that causes coccidioidomycosis in many arid regions of the Americas. One of these regions is bordered by the Caribbean Sea, and the surrounding landscape may play an important role in the dispersion of C. posadasii across South America through southeastern Mexico, Honduras, Guatemala, and Venezuela. Comparative phylogenomic analyses of C. posadasii reveal that clinical strains from Venezuela are genetically distinct from the North American populations found in (i) Arizona and (ii) Texas, Mexico, and the rest of South America (TX/MX/SA). We find evidence for admixture between the Venezuela and the North American populations of C. posadasii in Central America. Additionally, the proportion of Venezuelan alleles in the admixed population decreases as latitude (and distance from Venezuela) increases. Our results indicate that the population in Venezuela may have been subjected to a recent bottleneck and shows a strong population structure. This analysis provides insight into potential for Coccidioides spp. to invade new regions. IMPORTANCE Valley Fever is a fungal disease caused by two species of fungi: Coccidioides immitis and C. posadasii. These fungi are found throughout the arid regions of North and South America; however, our understanding of genetic diversity and disease in South America is limited. In this report, we analyze 10 new genomes of Coccidioides posadasii from regions bordering the Caribbean Sea. We show that these populations are distinct and that isolates from Venezuela are likely a result of a recent bottleneck. These data point to patterns that might be observed when investigating recently established populations.

Original languageEnglish (US)
Article numbere01976-19
JournalmBio
Volume10
Issue number6
DOIs
StatePublished - Nov 1 2019

Fingerprint

Coccidioides
Venezuela
Population Genetics
South America
Population
Coccidioidomycosis
Fungi
Mexico
Honduras
Guatemala
Central America
Inborn Genetic Diseases
Mycoses
Population Dynamics
North America
Oceans and Seas
Alleles
Genome

Keywords

  • Caribbean
  • Coccidioides posadasii
  • Coccidioidomycosis
  • Valley Fever
  • Venezuela

ASJC Scopus subject areas

  • Microbiology
  • Virology

Cite this

Teixeira, M. M., Alvarado, P., Roe, C. C., Thompson, G. R., Patané, J. S. L., Sahl, J. W., ... Barker, B. M. (2019). Population structure and genetic diversity among isolates of coccidioides posadasii in Venezuela and surrounding regions. mBio, 10(6), [e01976-19]. https://doi.org/10.1128/mBio.01976-19

Population structure and genetic diversity among isolates of coccidioides posadasii in Venezuela and surrounding regions. / Teixeira, Marcus M.; Alvarado, Primavera; Roe, Chandler C.; Thompson, George R.; Patané, José S.L.; Sahl, Jason W.; Keim, Paul; Galgiani, John N.; Litvintseva, Anastasia P.; Matute, Daniel R.; Barker, Bridget M.

In: mBio, Vol. 10, No. 6, e01976-19, 01.11.2019.

Research output: Contribution to journalArticle

Teixeira, MM, Alvarado, P, Roe, CC, Thompson, GR, Patané, JSL, Sahl, JW, Keim, P, Galgiani, JN, Litvintseva, AP, Matute, DR & Barker, BM 2019, 'Population structure and genetic diversity among isolates of coccidioides posadasii in Venezuela and surrounding regions', mBio, vol. 10, no. 6, e01976-19. https://doi.org/10.1128/mBio.01976-19
Teixeira, Marcus M. ; Alvarado, Primavera ; Roe, Chandler C. ; Thompson, George R. ; Patané, José S.L. ; Sahl, Jason W. ; Keim, Paul ; Galgiani, John N. ; Litvintseva, Anastasia P. ; Matute, Daniel R. ; Barker, Bridget M. / Population structure and genetic diversity among isolates of coccidioides posadasii in Venezuela and surrounding regions. In: mBio. 2019 ; Vol. 10, No. 6.
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abstract = "Coccidioides posadasii is a pathogenic fungus that causes coccidioidomycosis in many arid regions of the Americas. One of these regions is bordered by the Caribbean Sea, and the surrounding landscape may play an important role in the dispersion of C. posadasii across South America through southeastern Mexico, Honduras, Guatemala, and Venezuela. Comparative phylogenomic analyses of C. posadasii reveal that clinical strains from Venezuela are genetically distinct from the North American populations found in (i) Arizona and (ii) Texas, Mexico, and the rest of South America (TX/MX/SA). We find evidence for admixture between the Venezuela and the North American populations of C. posadasii in Central America. Additionally, the proportion of Venezuelan alleles in the admixed population decreases as latitude (and distance from Venezuela) increases. Our results indicate that the population in Venezuela may have been subjected to a recent bottleneck and shows a strong population structure. This analysis provides insight into potential for Coccidioides spp. to invade new regions. IMPORTANCE Valley Fever is a fungal disease caused by two species of fungi: Coccidioides immitis and C. posadasii. These fungi are found throughout the arid regions of North and South America; however, our understanding of genetic diversity and disease in South America is limited. In this report, we analyze 10 new genomes of Coccidioides posadasii from regions bordering the Caribbean Sea. We show that these populations are distinct and that isolates from Venezuela are likely a result of a recent bottleneck. These data point to patterns that might be observed when investigating recently established populations.",
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