Pilot study

Autologous platelet-rich plasma used in a topical cream for facial rejuvenation

Zoe Diana Draelos, Lawrence A. Rheins, Shaun Wootten, Robert S Kellar, Robert B. Diller

Research output: Contribution to journalArticle

Abstract

Background: Platelet rich plasma (PRP) is traditionally used as an injectable material for enhanced healing, hair growth, and facial rejuvenation. Aims: This research examined the novel use of topical autologously sourced PRP added to a preservative cosmetic base and applied twice daily to the face following electroporation for 8 weeks. Methods: 20 healthy female and male subjects 30-60 years of age were enrolled in this single-site, investigator blinded, vehicle controlled split-face study to evaluate the effect of a PRP-containing serum versus the serum alone on facial photoaging. Results: 90 day stability for the PRP in a preservative serum was achieved with refrigeration at 4 degrees Celsius. Facial skin biopsy histologic findings included improved rete peg architecture. Immunohistochemical analysis showed upregulation for collagen type I with qPCR data demonstrating concomitant upregulation of mRNA for collagen after 8 weeks of topical PRP use. Conclusion: These pilot study findings may indicate value for topical PRP in facial rejuvenation.

Original languageEnglish (US)
JournalJournal of Cosmetic Dermatology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Rejuvenation
Platelet-Rich Plasma
Up-Regulation
Serum
Refrigeration
Electroporation
Collagen Type I
Cosmetics
Hair
Collagen
Research Personnel
Biopsy
Messenger RNA
Skin
Injections
Growth
Research

Keywords

  • aging skin
  • cosmetics
  • facial rejuvenation
  • platelet-rich plasma
  • PRP

ASJC Scopus subject areas

  • Dermatology

Cite this

Pilot study : Autologous platelet-rich plasma used in a topical cream for facial rejuvenation. / Draelos, Zoe Diana; Rheins, Lawrence A.; Wootten, Shaun; Kellar, Robert S; Diller, Robert B.

In: Journal of Cosmetic Dermatology, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "Background: Platelet rich plasma (PRP) is traditionally used as an injectable material for enhanced healing, hair growth, and facial rejuvenation. Aims: This research examined the novel use of topical autologously sourced PRP added to a preservative cosmetic base and applied twice daily to the face following electroporation for 8 weeks. Methods: 20 healthy female and male subjects 30-60 years of age were enrolled in this single-site, investigator blinded, vehicle controlled split-face study to evaluate the effect of a PRP-containing serum versus the serum alone on facial photoaging. Results: 90 day stability for the PRP in a preservative serum was achieved with refrigeration at 4 degrees Celsius. Facial skin biopsy histologic findings included improved rete peg architecture. Immunohistochemical analysis showed upregulation for collagen type I with qPCR data demonstrating concomitant upregulation of mRNA for collagen after 8 weeks of topical PRP use. Conclusion: These pilot study findings may indicate value for topical PRP in facial rejuvenation.",
keywords = "aging skin, cosmetics, facial rejuvenation, platelet-rich plasma, PRP",
author = "Draelos, {Zoe Diana} and Rheins, {Lawrence A.} and Shaun Wootten and Kellar, {Robert S} and Diller, {Robert B.}",
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AU - Draelos, Zoe Diana

AU - Rheins, Lawrence A.

AU - Wootten, Shaun

AU - Kellar, Robert S

AU - Diller, Robert B.

PY - 2019/1/1

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N2 - Background: Platelet rich plasma (PRP) is traditionally used as an injectable material for enhanced healing, hair growth, and facial rejuvenation. Aims: This research examined the novel use of topical autologously sourced PRP added to a preservative cosmetic base and applied twice daily to the face following electroporation for 8 weeks. Methods: 20 healthy female and male subjects 30-60 years of age were enrolled in this single-site, investigator blinded, vehicle controlled split-face study to evaluate the effect of a PRP-containing serum versus the serum alone on facial photoaging. Results: 90 day stability for the PRP in a preservative serum was achieved with refrigeration at 4 degrees Celsius. Facial skin biopsy histologic findings included improved rete peg architecture. Immunohistochemical analysis showed upregulation for collagen type I with qPCR data demonstrating concomitant upregulation of mRNA for collagen after 8 weeks of topical PRP use. Conclusion: These pilot study findings may indicate value for topical PRP in facial rejuvenation.

AB - Background: Platelet rich plasma (PRP) is traditionally used as an injectable material for enhanced healing, hair growth, and facial rejuvenation. Aims: This research examined the novel use of topical autologously sourced PRP added to a preservative cosmetic base and applied twice daily to the face following electroporation for 8 weeks. Methods: 20 healthy female and male subjects 30-60 years of age were enrolled in this single-site, investigator blinded, vehicle controlled split-face study to evaluate the effect of a PRP-containing serum versus the serum alone on facial photoaging. Results: 90 day stability for the PRP in a preservative serum was achieved with refrigeration at 4 degrees Celsius. Facial skin biopsy histologic findings included improved rete peg architecture. Immunohistochemical analysis showed upregulation for collagen type I with qPCR data demonstrating concomitant upregulation of mRNA for collagen after 8 weeks of topical PRP use. Conclusion: These pilot study findings may indicate value for topical PRP in facial rejuvenation.

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