Pilot immunization of mice infected with an equine strain of Corynebacterium pseudotuberculosis

Jennifer K. Gorman, Mourad Gabriel, N. James MacLachlan, Nathan C Nieto, Janet E. Foley, Sharon J. Spier

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4 Scopus citations

Abstract

This pilot study evaluated protection of an equine autogenous bacterin-toxoid vaccine against Corynebacterium pseudotuberculosis infection. Twenty-four BALB/c mice were inoculated with two doses of bacterin-toxoid vaccine or two injections of a placebo. Clinical, microbiologic, and pathologic outcomes were assessed after intradermal infection with one of two equine-origin C. pseudotuberculosis strains. Mice receiving bacterin-toxoid from fast-growing C. pseudotuberculosis showed significant protection from challenge infection, as evidenced by a higher survival rate, fewer gross and histopathologic lesions, and lower bacterial levels on culture. Successful protection via a vaccine against equine internal abscesses might provide supplementary management options against an important, potentially fatal disease.

Original languageEnglish (US)
JournalVeterinary therapeutics : research in applied veterinary medicine
Volume11
Issue number1
StatePublished - 2010
Externally publishedYes

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ASJC Scopus subject areas

  • veterinary(all)

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