Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia

Gvantsa Chanturia, Dawn N. Birdsell, Merab Kekelidze, Ekaterine Zhgenti, George Babuadze, Nikoloz Tsertsvadze, Shota Tsanava, Paata Imnadze, Stephen M Beckstrom-Sternberg, James S. Beckstrom-Sternberg, Mia D. Champion, Shripad Sinari, Miklos Gyuranecz, Jason Farlow, Amanda H. Pettus, Emily L. Kaufman, Joseph D. Busch, Talima R Pearson, Jeffrey T Foster, Amy J. VoglerDavid M Wagner, Paul S Keim

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Francisella tularensis, the causative agent of tularemia, displays subspecies-specific differences in virulence, geographic distribution, and genetic diversity. F. tularensis subsp. holarctica is widely distributed throughout the Northern Hemisphere. In Europe, F. tularensis subsp. holarctica isolates have largely been assigned to two phylogenetic groups that have specific geographic distributions. Most isolates from Western Europe are assigned to the B.Br.FTNF002-00 group, whereas most isolates from Eastern Europe are assigned to numerous lineages within the B.Br.013 group. The eastern geographic extent of the B.Br.013 group is currently unknown due to a lack of phylogenetic knowledge about populations at the European/Asian juncture and in Asia. In this study, we address this knowledge gap by describing the phylogenetic structure of F. tularensis subsp. holarctica isolates from the country of Georgia, and by placing these isolates into a global phylogeographic context. Results: We identified a new genetic lineage of F. tularensis subsp. holarctica from Georgia that belongs to the B.Br.013 group. This new lineage is genetically and geographically distinct from lineages previously described from the B.Br.013 group from Central-Eastern Europe. Importantly, this new lineage is basal within the B.Br.013 group, indicating the Georgian lineage diverged before the diversification of the other known B.Br.013 lineages. Although two isolates from the Georgian lineage were collected nearby in the Ukrainian region of Crimea, all other global isolates assigned to this lineage were collected in Georgia. This restricted geographic distribution, as well as the high levels of genetic diversity within the lineage, is consistent with a relatively older origin and localized differentiation. Conclusions: We identified a new lineage of F. tularensis subsp. holarctica from Georgia that appears to have an older origin than any other diversified lineages previously described from the B.Br.013 group. This finding suggests that additional phylogenetic studies of F. tularensis subsp. holarctica populations in Eastern Europe and Asia have the potential to yield important new insights into the evolutionary history and phylogeography of this broadly dispersed F. tularensis subspecies.

Original languageEnglish (US)
Article number139
JournalBMC Microbiology
Volume11
DOIs
StatePublished - 2011

Fingerprint

Francisella tularensis
Phylogeography
Eastern Europe
Tularemia
Far East
Population
Virulence
History

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Chanturia, G., Birdsell, D. N., Kekelidze, M., Zhgenti, E., Babuadze, G., Tsertsvadze, N., ... Keim, P. S. (2011). Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia. BMC Microbiology, 11, [139]. https://doi.org/10.1186/1471-2180-11-139

Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia. / Chanturia, Gvantsa; Birdsell, Dawn N.; Kekelidze, Merab; Zhgenti, Ekaterine; Babuadze, George; Tsertsvadze, Nikoloz; Tsanava, Shota; Imnadze, Paata; Beckstrom-Sternberg, Stephen M; Beckstrom-Sternberg, James S.; Champion, Mia D.; Sinari, Shripad; Gyuranecz, Miklos; Farlow, Jason; Pettus, Amanda H.; Kaufman, Emily L.; Busch, Joseph D.; Pearson, Talima R; Foster, Jeffrey T; Vogler, Amy J.; Wagner, David M; Keim, Paul S.

In: BMC Microbiology, Vol. 11, 139, 2011.

Research output: Contribution to journalArticle

Chanturia, G, Birdsell, DN, Kekelidze, M, Zhgenti, E, Babuadze, G, Tsertsvadze, N, Tsanava, S, Imnadze, P, Beckstrom-Sternberg, SM, Beckstrom-Sternberg, JS, Champion, MD, Sinari, S, Gyuranecz, M, Farlow, J, Pettus, AH, Kaufman, EL, Busch, JD, Pearson, TR, Foster, JT, Vogler, AJ, Wagner, DM & Keim, PS 2011, 'Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia', BMC Microbiology, vol. 11, 139. https://doi.org/10.1186/1471-2180-11-139
Chanturia G, Birdsell DN, Kekelidze M, Zhgenti E, Babuadze G, Tsertsvadze N et al. Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia. BMC Microbiology. 2011;11. 139. https://doi.org/10.1186/1471-2180-11-139
Chanturia, Gvantsa ; Birdsell, Dawn N. ; Kekelidze, Merab ; Zhgenti, Ekaterine ; Babuadze, George ; Tsertsvadze, Nikoloz ; Tsanava, Shota ; Imnadze, Paata ; Beckstrom-Sternberg, Stephen M ; Beckstrom-Sternberg, James S. ; Champion, Mia D. ; Sinari, Shripad ; Gyuranecz, Miklos ; Farlow, Jason ; Pettus, Amanda H. ; Kaufman, Emily L. ; Busch, Joseph D. ; Pearson, Talima R ; Foster, Jeffrey T ; Vogler, Amy J. ; Wagner, David M ; Keim, Paul S. / Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia. In: BMC Microbiology. 2011 ; Vol. 11.
@article{c2b202b97404483d8ae93643fb3f99c4,
title = "Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia",
abstract = "Background: Francisella tularensis, the causative agent of tularemia, displays subspecies-specific differences in virulence, geographic distribution, and genetic diversity. F. tularensis subsp. holarctica is widely distributed throughout the Northern Hemisphere. In Europe, F. tularensis subsp. holarctica isolates have largely been assigned to two phylogenetic groups that have specific geographic distributions. Most isolates from Western Europe are assigned to the B.Br.FTNF002-00 group, whereas most isolates from Eastern Europe are assigned to numerous lineages within the B.Br.013 group. The eastern geographic extent of the B.Br.013 group is currently unknown due to a lack of phylogenetic knowledge about populations at the European/Asian juncture and in Asia. In this study, we address this knowledge gap by describing the phylogenetic structure of F. tularensis subsp. holarctica isolates from the country of Georgia, and by placing these isolates into a global phylogeographic context. Results: We identified a new genetic lineage of F. tularensis subsp. holarctica from Georgia that belongs to the B.Br.013 group. This new lineage is genetically and geographically distinct from lineages previously described from the B.Br.013 group from Central-Eastern Europe. Importantly, this new lineage is basal within the B.Br.013 group, indicating the Georgian lineage diverged before the diversification of the other known B.Br.013 lineages. Although two isolates from the Georgian lineage were collected nearby in the Ukrainian region of Crimea, all other global isolates assigned to this lineage were collected in Georgia. This restricted geographic distribution, as well as the high levels of genetic diversity within the lineage, is consistent with a relatively older origin and localized differentiation. Conclusions: We identified a new lineage of F. tularensis subsp. holarctica from Georgia that appears to have an older origin than any other diversified lineages previously described from the B.Br.013 group. This finding suggests that additional phylogenetic studies of F. tularensis subsp. holarctica populations in Eastern Europe and Asia have the potential to yield important new insights into the evolutionary history and phylogeography of this broadly dispersed F. tularensis subspecies.",
author = "Gvantsa Chanturia and Birdsell, {Dawn N.} and Merab Kekelidze and Ekaterine Zhgenti and George Babuadze and Nikoloz Tsertsvadze and Shota Tsanava and Paata Imnadze and Beckstrom-Sternberg, {Stephen M} and Beckstrom-Sternberg, {James S.} and Champion, {Mia D.} and Shripad Sinari and Miklos Gyuranecz and Jason Farlow and Pettus, {Amanda H.} and Kaufman, {Emily L.} and Busch, {Joseph D.} and Pearson, {Talima R} and Foster, {Jeffrey T} and Vogler, {Amy J.} and Wagner, {David M} and Keim, {Paul S}",
year = "2011",
doi = "10.1186/1471-2180-11-139",
language = "English (US)",
volume = "11",
journal = "BMC Microbiology",
issn = "1471-2180",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia

AU - Chanturia, Gvantsa

AU - Birdsell, Dawn N.

AU - Kekelidze, Merab

AU - Zhgenti, Ekaterine

AU - Babuadze, George

AU - Tsertsvadze, Nikoloz

AU - Tsanava, Shota

AU - Imnadze, Paata

AU - Beckstrom-Sternberg, Stephen M

AU - Beckstrom-Sternberg, James S.

AU - Champion, Mia D.

AU - Sinari, Shripad

AU - Gyuranecz, Miklos

AU - Farlow, Jason

AU - Pettus, Amanda H.

AU - Kaufman, Emily L.

AU - Busch, Joseph D.

AU - Pearson, Talima R

AU - Foster, Jeffrey T

AU - Vogler, Amy J.

AU - Wagner, David M

AU - Keim, Paul S

PY - 2011

Y1 - 2011

N2 - Background: Francisella tularensis, the causative agent of tularemia, displays subspecies-specific differences in virulence, geographic distribution, and genetic diversity. F. tularensis subsp. holarctica is widely distributed throughout the Northern Hemisphere. In Europe, F. tularensis subsp. holarctica isolates have largely been assigned to two phylogenetic groups that have specific geographic distributions. Most isolates from Western Europe are assigned to the B.Br.FTNF002-00 group, whereas most isolates from Eastern Europe are assigned to numerous lineages within the B.Br.013 group. The eastern geographic extent of the B.Br.013 group is currently unknown due to a lack of phylogenetic knowledge about populations at the European/Asian juncture and in Asia. In this study, we address this knowledge gap by describing the phylogenetic structure of F. tularensis subsp. holarctica isolates from the country of Georgia, and by placing these isolates into a global phylogeographic context. Results: We identified a new genetic lineage of F. tularensis subsp. holarctica from Georgia that belongs to the B.Br.013 group. This new lineage is genetically and geographically distinct from lineages previously described from the B.Br.013 group from Central-Eastern Europe. Importantly, this new lineage is basal within the B.Br.013 group, indicating the Georgian lineage diverged before the diversification of the other known B.Br.013 lineages. Although two isolates from the Georgian lineage were collected nearby in the Ukrainian region of Crimea, all other global isolates assigned to this lineage were collected in Georgia. This restricted geographic distribution, as well as the high levels of genetic diversity within the lineage, is consistent with a relatively older origin and localized differentiation. Conclusions: We identified a new lineage of F. tularensis subsp. holarctica from Georgia that appears to have an older origin than any other diversified lineages previously described from the B.Br.013 group. This finding suggests that additional phylogenetic studies of F. tularensis subsp. holarctica populations in Eastern Europe and Asia have the potential to yield important new insights into the evolutionary history and phylogeography of this broadly dispersed F. tularensis subspecies.

AB - Background: Francisella tularensis, the causative agent of tularemia, displays subspecies-specific differences in virulence, geographic distribution, and genetic diversity. F. tularensis subsp. holarctica is widely distributed throughout the Northern Hemisphere. In Europe, F. tularensis subsp. holarctica isolates have largely been assigned to two phylogenetic groups that have specific geographic distributions. Most isolates from Western Europe are assigned to the B.Br.FTNF002-00 group, whereas most isolates from Eastern Europe are assigned to numerous lineages within the B.Br.013 group. The eastern geographic extent of the B.Br.013 group is currently unknown due to a lack of phylogenetic knowledge about populations at the European/Asian juncture and in Asia. In this study, we address this knowledge gap by describing the phylogenetic structure of F. tularensis subsp. holarctica isolates from the country of Georgia, and by placing these isolates into a global phylogeographic context. Results: We identified a new genetic lineage of F. tularensis subsp. holarctica from Georgia that belongs to the B.Br.013 group. This new lineage is genetically and geographically distinct from lineages previously described from the B.Br.013 group from Central-Eastern Europe. Importantly, this new lineage is basal within the B.Br.013 group, indicating the Georgian lineage diverged before the diversification of the other known B.Br.013 lineages. Although two isolates from the Georgian lineage were collected nearby in the Ukrainian region of Crimea, all other global isolates assigned to this lineage were collected in Georgia. This restricted geographic distribution, as well as the high levels of genetic diversity within the lineage, is consistent with a relatively older origin and localized differentiation. Conclusions: We identified a new lineage of F. tularensis subsp. holarctica from Georgia that appears to have an older origin than any other diversified lineages previously described from the B.Br.013 group. This finding suggests that additional phylogenetic studies of F. tularensis subsp. holarctica populations in Eastern Europe and Asia have the potential to yield important new insights into the evolutionary history and phylogeography of this broadly dispersed F. tularensis subspecies.

UR - http://www.scopus.com/inward/record.url?scp=79958839942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958839942&partnerID=8YFLogxK

U2 - 10.1186/1471-2180-11-139

DO - 10.1186/1471-2180-11-139

M3 - Article

C2 - 21682874

AN - SCOPUS:79958839942

VL - 11

JO - BMC Microbiology

JF - BMC Microbiology

SN - 1471-2180

M1 - 139

ER -