Photoactivated uranyl ion produces single strand breaks in plasmid DNA

Shannon A. George, Aaron M. Whittaker, Diane M Stearns

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Uranium is an important emerging toxicant whose use has outpaced the rate at which we are learning about its health effects. One unexplored pathway for uranium toxicity involves the photoactivation of uranyl ion by UV light to produce U 5+ and oxygen radicals. The purpose of this study was to provide proof of principle data by testing the hypothesis that coexposures of DNA to uranyl acetate and UVB irradiation should produce more DNA strand breaks than individual exposures. Results supported the hypothesis and suggest that investigations of uranium toxicity be expanded to include skin as a potential target organ for carcinogenesis, especially in populations with high uranium and high UV radiation exposures.

Original languageEnglish (US)
Pages (from-to)1830-1832
Number of pages3
JournalChemical Research in Toxicology
Volume24
Issue number11
DOIs
StatePublished - Nov 21 2011

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Uranium
Plasmids
Ions
DNA
Ultraviolet radiation
Toxicity
DNA Breaks
Ultraviolet Rays
Reactive Oxygen Species
Skin
Carcinogenesis
Health
Learning
Irradiation
Testing
Population

ASJC Scopus subject areas

  • Toxicology

Cite this

Photoactivated uranyl ion produces single strand breaks in plasmid DNA. / George, Shannon A.; Whittaker, Aaron M.; Stearns, Diane M.

In: Chemical Research in Toxicology, Vol. 24, No. 11, 21.11.2011, p. 1830-1832.

Research output: Contribution to journalArticle

George, Shannon A. ; Whittaker, Aaron M. ; Stearns, Diane M. / Photoactivated uranyl ion produces single strand breaks in plasmid DNA. In: Chemical Research in Toxicology. 2011 ; Vol. 24, No. 11. pp. 1830-1832.
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