### Abstract

Data from eighteen subjects, studied in hypoxia (minimum PI_{O2} = 80 Torr) both at rest and during exercise, were analyzed using computer models which estimate O_{2} diffusing capacity from measured V̇A/Q̇ distributions (obtained using the multiple inert gas elimination technique 'MIGET') and measured O_{2} exchange. Two of these models assigned the distribution of the diffusing capacity (D) in proportion to either the perfusion (DL_{O2}-Vwt) distributions from MIGET, and thus modeled the effects of V̇A/Q̇ and D/Q̇β(where Q̇β is the perfusive conductance inequalities respectively. The third model (DL_{O2}-3C) assigned all the diffusing capacity to a single homogeneous compartment. At rest DL_{O2} was 41.1 ± 41.4 ± 5.4 and 30.2 ± 2.1 ml · min^{-1} · Torr^{-1} for the Qwt, Vwt and 3C models respectively. These rose to 93.7 ± 2.6, 109.3 ± 4.5 and 81.1 ± 1.9 ml · min^{-1} · Torr^{-1} respectively at maximal exercise, all significantly different from rest (P < 0.001 for each). The effects of measured V̇A/Q̇ and theoretical D/Q̇β inhomogeneities on diffusing capacity estimates were significant even in normal lungs. Both types of inequality caused an appreciable underestimation of DL_{O2}. These multi-compartment model estimates, using real data, are consistent with published theoretical predictions of the effects of V̇, Q̇ and D inequalities. These results during exercise come close to morphometric predictions of maximal oxygen diffusing capacity in man.

Original language | English (US) |
---|---|

Pages (from-to) | 129-147 |

Number of pages | 19 |

Journal | Respiration Physiology |

Volume | 69 |

Issue number | 2 |

DOIs | |

State | Published - 1987 |

Externally published | Yes |

### Fingerprint

### Keywords

- Exercise
- Hypoxia
- Inert gases
- Lung models
- Pulmonary gas exchange

### ASJC Scopus subject areas

- Physiology
- Pulmonary and Respiratory Medicine

### Cite this

*Respiration Physiology*,

*69*(2), 129-147. https://doi.org/10.1016/0034-5687(87)90022-3

**Oxygen diffusing capacity estimates derived from measured V̇A/Q̇ distributions in man.** / Hammond, M. D.; Hempleman, Steven C.

Research output: Contribution to journal › Article

*Respiration Physiology*, vol. 69, no. 2, pp. 129-147. https://doi.org/10.1016/0034-5687(87)90022-3

}

TY - JOUR

T1 - Oxygen diffusing capacity estimates derived from measured V̇A/Q̇ distributions in man

AU - Hammond, M. D.

AU - Hempleman, Steven C

PY - 1987

Y1 - 1987

N2 - Data from eighteen subjects, studied in hypoxia (minimum PIO2 = 80 Torr) both at rest and during exercise, were analyzed using computer models which estimate O2 diffusing capacity from measured V̇A/Q̇ distributions (obtained using the multiple inert gas elimination technique 'MIGET') and measured O2 exchange. Two of these models assigned the distribution of the diffusing capacity (D) in proportion to either the perfusion (DLO2-Vwt) distributions from MIGET, and thus modeled the effects of V̇A/Q̇ and D/Q̇β(where Q̇β is the perfusive conductance inequalities respectively. The third model (DLO2-3C) assigned all the diffusing capacity to a single homogeneous compartment. At rest DLO2 was 41.1 ± 41.4 ± 5.4 and 30.2 ± 2.1 ml · min-1 · Torr-1 for the Qwt, Vwt and 3C models respectively. These rose to 93.7 ± 2.6, 109.3 ± 4.5 and 81.1 ± 1.9 ml · min-1 · Torr-1 respectively at maximal exercise, all significantly different from rest (P < 0.001 for each). The effects of measured V̇A/Q̇ and theoretical D/Q̇β inhomogeneities on diffusing capacity estimates were significant even in normal lungs. Both types of inequality caused an appreciable underestimation of DLO2. These multi-compartment model estimates, using real data, are consistent with published theoretical predictions of the effects of V̇, Q̇ and D inequalities. These results during exercise come close to morphometric predictions of maximal oxygen diffusing capacity in man.

AB - Data from eighteen subjects, studied in hypoxia (minimum PIO2 = 80 Torr) both at rest and during exercise, were analyzed using computer models which estimate O2 diffusing capacity from measured V̇A/Q̇ distributions (obtained using the multiple inert gas elimination technique 'MIGET') and measured O2 exchange. Two of these models assigned the distribution of the diffusing capacity (D) in proportion to either the perfusion (DLO2-Vwt) distributions from MIGET, and thus modeled the effects of V̇A/Q̇ and D/Q̇β(where Q̇β is the perfusive conductance inequalities respectively. The third model (DLO2-3C) assigned all the diffusing capacity to a single homogeneous compartment. At rest DLO2 was 41.1 ± 41.4 ± 5.4 and 30.2 ± 2.1 ml · min-1 · Torr-1 for the Qwt, Vwt and 3C models respectively. These rose to 93.7 ± 2.6, 109.3 ± 4.5 and 81.1 ± 1.9 ml · min-1 · Torr-1 respectively at maximal exercise, all significantly different from rest (P < 0.001 for each). The effects of measured V̇A/Q̇ and theoretical D/Q̇β inhomogeneities on diffusing capacity estimates were significant even in normal lungs. Both types of inequality caused an appreciable underestimation of DLO2. These multi-compartment model estimates, using real data, are consistent with published theoretical predictions of the effects of V̇, Q̇ and D inequalities. These results during exercise come close to morphometric predictions of maximal oxygen diffusing capacity in man.

KW - Exercise

KW - Hypoxia

KW - Inert gases

KW - Lung models

KW - Pulmonary gas exchange

UR - http://www.scopus.com/inward/record.url?scp=0023244597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023244597&partnerID=8YFLogxK

U2 - 10.1016/0034-5687(87)90022-3

DO - 10.1016/0034-5687(87)90022-3

M3 - Article

VL - 69

SP - 129

EP - 147

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 2

ER -