Multivariate calibration in inductively coupled plasma mass spectrometry

Michael E Ketterer, J. J. Reschl, M. J. Peters

Research output: Contribution to journalArticle

43 Scopus citations


To date, the existence of isobaric molecular ion interferences resulting from the formation of species such as MO+ and MCI+ has been considered to be a significant shortcoming of inductively coupled plasma mass spectrometry (ICP/MS). In the present study, this problem has been circumvented through the use of two multivariate calibration methods, namely multiple linear regression (MLR) and principal components regression (PCR). The methods function by utilizing information from multiple, partially selective sensors and have been applied to the nMo16O+/n+16Cd+ and nZr16O+, nMo16O+, nRu16O+/n+16Cd+, n+16In+, n+16Sn+ systems.

Original languageEnglish (US)
Pages (from-to)2031-2040
Number of pages10
JournalAnalytical Chemistry
Issue number18
StatePublished - Jan 1 1989
Externally publishedYes


ASJC Scopus subject areas

  • Analytical Chemistry

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