Meso-scale ecology of anthrax in Southern Africa: A pilot study of diversity and clustering

K. L. Smith, V. De Vos, H. B. Bryden, M. E. Hugh-Janes, A. Klevytska, L. B. Price, Paul S Keim, D. T. Scholl

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

It has only recently been possible to detect sufficient genetic diversity among anthrax isolates to allow genotype grouping (Keim et al. 1997). Early results of such grouping suggest that the southern African subcontinent may be the geographical origin of Bacillus anthracis. This report describes a pilot investigation of the genetic diversity of a study group of isolates from the Kruger National Park, South Africa, and efforts to detect spatio-temporal clustering within the study group. This study has also served as further validation for the newly developed Multi-Locus VNTR Analysis (MLVA), designed to simplify genotyping of B. anthracis isolates. The results reveal a diverse range of genotypes within the park allied with three genotype reference groups, and show that the MLVA procedure is robust for rapid analysis of B. anthracis genotypes. We also observed multiple genotype groups within epidemics and between geographically and temporally close epidemic episodes. This is in contrast to earlier characterizations of anthrax epidemics. The result of a Mantel test for time-space clustering indicates clustering of the anthrax isolates selected for the study.

Original languageEnglish (US)
Pages (from-to)204-207
Number of pages4
JournalJournal of Applied Microbiology
Volume87
Issue number2
DOIs
StatePublished - 1999

Fingerprint

Southern Africa
Anthrax
anthrax
Ecology
Cluster Analysis
Bacillus anthracis
Genotype
ecology
genotype
Minisatellite Repeats
minisatellite repeats
Space-Time Clustering
genetic variation
South Africa
genotyping
national parks
testing

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Applied Microbiology and Biotechnology
  • Biotechnology
  • Microbiology

Cite this

Smith, K. L., De Vos, V., Bryden, H. B., Hugh-Janes, M. E., Klevytska, A., Price, L. B., ... Scholl, D. T. (1999). Meso-scale ecology of anthrax in Southern Africa: A pilot study of diversity and clustering. Journal of Applied Microbiology, 87(2), 204-207. https://doi.org/10.1046/j.1365-2672.1999.00871.x

Meso-scale ecology of anthrax in Southern Africa : A pilot study of diversity and clustering. / Smith, K. L.; De Vos, V.; Bryden, H. B.; Hugh-Janes, M. E.; Klevytska, A.; Price, L. B.; Keim, Paul S; Scholl, D. T.

In: Journal of Applied Microbiology, Vol. 87, No. 2, 1999, p. 204-207.

Research output: Contribution to journalArticle

Smith, KL, De Vos, V, Bryden, HB, Hugh-Janes, ME, Klevytska, A, Price, LB, Keim, PS & Scholl, DT 1999, 'Meso-scale ecology of anthrax in Southern Africa: A pilot study of diversity and clustering', Journal of Applied Microbiology, vol. 87, no. 2, pp. 204-207. https://doi.org/10.1046/j.1365-2672.1999.00871.x
Smith, K. L. ; De Vos, V. ; Bryden, H. B. ; Hugh-Janes, M. E. ; Klevytska, A. ; Price, L. B. ; Keim, Paul S ; Scholl, D. T. / Meso-scale ecology of anthrax in Southern Africa : A pilot study of diversity and clustering. In: Journal of Applied Microbiology. 1999 ; Vol. 87, No. 2. pp. 204-207.
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