Mechanistic insights into the success of xenobiotic degraders resolved from metagenomes of microbial enrichment cultures

Junhui Li, Chongjian Jia, Qihong Lu, Bruce A. Hungate, Paul Dijkstra, Shanquan Wang, Cuiyu Wu, Shaohua Chen, Deqiang Li, Hojae Shim

Research output: Contribution to journalArticlepeer-review

Abstract

Even though microbial communities can be more effective at degrading xenobiotics than cultured micro-organisms, yet little is known about the microbial strategies that underpin xenobiotic biodegradation by microbial communities. Here, we employ metagenomic community sequencing to explore the mechanisms that drive the development of 49 xenobiotic-degrading microbial communities, which were enriched from 7 contaminated soils or sediments with a range of xenobiotic compounds. We show that multiple microbial strategies likely drive the development of xenobiotic degrading communities, notably (i) presence of genes encoding catabolic enzymes to degrade xenobiotics; (ii) presence of genes encoding efflux pumps; (iii) auxiliary catabolic genes on plasmids; and (iv) positive interactions dominate microbial communities with efficient degradation. Overall, the integrated analyses of microbial ecological strategies advance our understanding of microbial processes driving the biodegradation of xenobiotics and promote the design of bioremediation systems.

Original languageEnglish (US)
Article number126384
JournalJournal of Hazardous Materials
Volume418
DOIs
StatePublished - Sep 15 2021

Keywords

  • Efflux pump
  • Interaction
  • Mechanism
  • Metagenome
  • Plasmid
  • Xenobiotic catabolism

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution
  • Health, Toxicology and Mutagenesis

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