Mass spectrometric fragmentation patterns for the Syn and anti isomers of PGE2 and PGD2-methyloxime methyl esters and their analogs

Cynthia J Hartzell, N. H. Andersen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A systematic study of the mass spectral fragmentation of the methyl ester-methyloxime-trimethylsilyl ether derivatives of D and E prostaglandins and selected ω-chain analogs is presented. Fragments from the ω-chain analogs are shifted the appropriate mass when compared with the parent PGD2 or PGE2. NMR data of the methyloxime methyl ester of PGE2 have permitted assignment of the syn and anti isomers (relative to the α chain) to the fast and slow eluting gas chromatographic peaks, respectively.

Original languageEnglish (US)
Pages (from-to)303-308
Number of pages6
JournalBiomedical Mass Spectrometry
Volume12
Issue number7
StatePublished - 1985
Externally publishedYes

Fingerprint

Prostaglandins D
Prostaglandin D2
Prostaglandins E
Dinoprostone
Isomers
Ether
Esters
Gases
Nuclear magnetic resonance
Derivatives
Ethers
prostaglandin E2 methyl ester
prostaglandin D2 methyl ester

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pollution

Cite this

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AB - A systematic study of the mass spectral fragmentation of the methyl ester-methyloxime-trimethylsilyl ether derivatives of D and E prostaglandins and selected ω-chain analogs is presented. Fragments from the ω-chain analogs are shifted the appropriate mass when compared with the parent PGD2 or PGE2. NMR data of the methyloxime methyl ester of PGE2 have permitted assignment of the syn and anti isomers (relative to the α chain) to the fast and slow eluting gas chromatographic peaks, respectively.

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