Low molecular weight immunosuppressors secreted by adult Nematospiroides dubius

Fernando G. Monroy, Colin Dobson, John H. Adams

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Low molecular weight immunosuppressors secreted by adult Nematospiroides dubius. International Journal for Parasitology 19: 125-127. Adult Nematospiroides dubius excretory-secretory products (ES) were collected from worms cultured in vitro, separated by sodium dodecyi sulphatepolyacrylamide gel electrophoresis (SDS-PAGE) into four fractions (FI-IV), electroeluted and assessed for their ability to inhibit the proliferation of mouse lymphocytes stimulated by mitogens in vitro. The proliferation of milogen- and ES-stimulated mouse spleen lymphocytes from normal and infected mice was inhibited by low mol. wt ES F-IV (<26,000).

Original languageEnglish (US)
Pages (from-to)125-127
Number of pages3
JournalInternational Journal for Parasitology
Volume19
Issue number1
DOIs
StatePublished - Feb 1989
Externally publishedYes

Keywords

  • Nemalospiroides dubius
  • excretory-secretory antigens
  • immunosuppression
  • mitogens

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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