Investigation of DNA sensing using piezoresistive microcantilever probes

Robert L. Gunter, Rosalie Zhine, William G Delinger, Kevin Manygoats, Ara Kooser, Timothy L. Porter

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Piezoresistive microcantilever-based sensors maybe used in a variety of sensing applications, including chemical sensing and biological sensing. In these applications, a sensing material is functionalized so as to undergo a volumetric or dimensional change upon analyte exposure. A piezoresistive microcantilever in contact with, or embedded within, the sensing material records the dimensional change as a simple resistance change in the cantilever as it is strained by the volumetric shift in the sensing layer. Here, we describe the detection of single-strand DNA by utilizing a sensing layer material consisting of thiolated single-strand DNA attached to a gold film substrate. A piezoresistive microcantilever in direct contact with this layer in solution immediately responds to the presence of the complimentary (25 base) single strand.

Original languageEnglish (US)
Pages (from-to)430-433
Number of pages4
JournalIEEE Sensors Journal
Volume4
Issue number4
DOIs
StatePublished - Aug 2004

Fingerprint

DNA
deoxyribonucleic acid
probes
strands
Contacts (fluid mechanics)
Gold
Sensors
Substrates
gold
shift
sensors

Keywords

  • Cantilever
  • DNA
  • Piezoresistive
  • Sensor

ASJC Scopus subject areas

  • Engineering(all)
  • Electrical and Electronic Engineering

Cite this

Investigation of DNA sensing using piezoresistive microcantilever probes. / Gunter, Robert L.; Zhine, Rosalie; Delinger, William G; Manygoats, Kevin; Kooser, Ara; Porter, Timothy L.

In: IEEE Sensors Journal, Vol. 4, No. 4, 08.2004, p. 430-433.

Research output: Contribution to journalArticle

Gunter, RL, Zhine, R, Delinger, WG, Manygoats, K, Kooser, A & Porter, TL 2004, 'Investigation of DNA sensing using piezoresistive microcantilever probes', IEEE Sensors Journal, vol. 4, no. 4, pp. 430-433. https://doi.org/10.1109/JSEN.2004.829784
Gunter, Robert L. ; Zhine, Rosalie ; Delinger, William G ; Manygoats, Kevin ; Kooser, Ara ; Porter, Timothy L. / Investigation of DNA sensing using piezoresistive microcantilever probes. In: IEEE Sensors Journal. 2004 ; Vol. 4, No. 4. pp. 430-433.
@article{452d508e8fb94dfca7e4ee9b1d0d618a,
title = "Investigation of DNA sensing using piezoresistive microcantilever probes",
abstract = "Piezoresistive microcantilever-based sensors maybe used in a variety of sensing applications, including chemical sensing and biological sensing. In these applications, a sensing material is functionalized so as to undergo a volumetric or dimensional change upon analyte exposure. A piezoresistive microcantilever in contact with, or embedded within, the sensing material records the dimensional change as a simple resistance change in the cantilever as it is strained by the volumetric shift in the sensing layer. Here, we describe the detection of single-strand DNA by utilizing a sensing layer material consisting of thiolated single-strand DNA attached to a gold film substrate. A piezoresistive microcantilever in direct contact with this layer in solution immediately responds to the presence of the complimentary (25 base) single strand.",
keywords = "Cantilever, DNA, Piezoresistive, Sensor",
author = "Gunter, {Robert L.} and Rosalie Zhine and Delinger, {William G} and Kevin Manygoats and Ara Kooser and Porter, {Timothy L.}",
year = "2004",
month = "8",
doi = "10.1109/JSEN.2004.829784",
language = "English (US)",
volume = "4",
pages = "430--433",
journal = "IEEE Sensors Journal",
issn = "1530-437X",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "4",

}

TY - JOUR

T1 - Investigation of DNA sensing using piezoresistive microcantilever probes

AU - Gunter, Robert L.

AU - Zhine, Rosalie

AU - Delinger, William G

AU - Manygoats, Kevin

AU - Kooser, Ara

AU - Porter, Timothy L.

PY - 2004/8

Y1 - 2004/8

N2 - Piezoresistive microcantilever-based sensors maybe used in a variety of sensing applications, including chemical sensing and biological sensing. In these applications, a sensing material is functionalized so as to undergo a volumetric or dimensional change upon analyte exposure. A piezoresistive microcantilever in contact with, or embedded within, the sensing material records the dimensional change as a simple resistance change in the cantilever as it is strained by the volumetric shift in the sensing layer. Here, we describe the detection of single-strand DNA by utilizing a sensing layer material consisting of thiolated single-strand DNA attached to a gold film substrate. A piezoresistive microcantilever in direct contact with this layer in solution immediately responds to the presence of the complimentary (25 base) single strand.

AB - Piezoresistive microcantilever-based sensors maybe used in a variety of sensing applications, including chemical sensing and biological sensing. In these applications, a sensing material is functionalized so as to undergo a volumetric or dimensional change upon analyte exposure. A piezoresistive microcantilever in contact with, or embedded within, the sensing material records the dimensional change as a simple resistance change in the cantilever as it is strained by the volumetric shift in the sensing layer. Here, we describe the detection of single-strand DNA by utilizing a sensing layer material consisting of thiolated single-strand DNA attached to a gold film substrate. A piezoresistive microcantilever in direct contact with this layer in solution immediately responds to the presence of the complimentary (25 base) single strand.

KW - Cantilever

KW - DNA

KW - Piezoresistive

KW - Sensor

UR - http://www.scopus.com/inward/record.url?scp=3142667579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3142667579&partnerID=8YFLogxK

U2 - 10.1109/JSEN.2004.829784

DO - 10.1109/JSEN.2004.829784

M3 - Article

VL - 4

SP - 430

EP - 433

JO - IEEE Sensors Journal

JF - IEEE Sensors Journal

SN - 1530-437X

IS - 4

ER -