Inhibition of skeletal muscle activity by lung expansion in the dog

Richard J Coast, G. S. Thompson, S. S. Cassidy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The ability of lung expansion to reflexly decrease skeletal muscle activity was tested in anesthetized dogs. In animals whose left lung was vascularly isolated but neurally intact, the left lung was inflated statically to 40 cmH2O pressure or cyclically with tidal volumes of 10, 20 or 30 ml/kg. Responses to these stimuli were compared with those of injecting 120 or 240 μg capsaicin into the left pulmonary artery. Skeletal muscle activity was assessed from the electromyogram (EMG) response of the left hindlimb muscles and from the monosynaptic reflex response to a periodic patellar tendon tap of the right leg (knee jerk). Static inflation and cyclic inflations above 10 ml/kg resulted in significant decreases in both EMG and knee jerk responses. The results indicate that lung expansion is capable of initiating a reflex decrease in skeletal muscle activity. Capsaicin injections caused responses that were similar to those caused by lung inflation, suggesting that at least part of this skeletal muscle reflex response to lung inflation can be attributed to the stimulation of pulmonary C-fibers that could be caused by stretch of the lung.

Original languageEnglish (US)
Pages (from-to)2058-2065
Number of pages8
JournalJournal of Applied Physiology
Volume62
Issue number5
StatePublished - 1987
Externally publishedYes

Fingerprint

Skeletal Muscle
Dogs
Lung
Economic Inflation
Capsaicin
Electromyography
Reflex
Knee
Monosynaptic Reflex
Patellar Ligament
Unmyelinated Nerve Fibers
Aptitude
Inhibition (Psychology)
Tidal Volume
Hindlimb
Pulmonary Artery
Leg
Pressure
Muscles
Injections

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Inhibition of skeletal muscle activity by lung expansion in the dog. / Coast, Richard J; Thompson, G. S.; Cassidy, S. S.

In: Journal of Applied Physiology, Vol. 62, No. 5, 1987, p. 2058-2065.

Research output: Contribution to journalArticle

Coast, RJ, Thompson, GS & Cassidy, SS 1987, 'Inhibition of skeletal muscle activity by lung expansion in the dog', Journal of Applied Physiology, vol. 62, no. 5, pp. 2058-2065.
Coast, Richard J ; Thompson, G. S. ; Cassidy, S. S. / Inhibition of skeletal muscle activity by lung expansion in the dog. In: Journal of Applied Physiology. 1987 ; Vol. 62, No. 5. pp. 2058-2065.
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