Individual diet has sex-dependent effects on vertebrate gut microbiota

Daniel I. Bolnick, Lisa K. Snowberg, Philipp E. Hirsch, Christian L. Lauber, Elin Org, Brian Parks, Aldons J. Lusis, Rob Knight, James G Caporaso, Richard Svanbäck

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Vertebrates harbour diverse communities of symbiotic gut microbes. Host diet is known to alter microbiota composition, implying that dietary treatments might alleviate diseases arising from altered microbial composition (ẫ dysbiosisâ(tm)). However, it remains unclear whether diet effects are general or depend on host genotype. Here we show that gut microbiota composition depends on interactions between host diet and sex within populations of wild and laboratory fish, laboratory mice and humans. Within each of two natural fish populations (threespine stickleback and Eurasian perch), among-individual diet variation is correlated with individual differences in gut microbiota. However, these diet-microbiota associations are sex dependent. We document similar sex-specific diet-microbiota correlations in humans. Experimental diet manipulations in laboratory stickleback and mice confirmed that diet affects microbiota differently in males versus females. The prevalence of such genotype by environment (sex by diet) interactions implies that therapies to treat dysbiosis might have sex-specific effects.

Original languageEnglish (US)
Article number4500
JournalNature Communications
Volume5
DOIs
StatePublished - Jul 29 2014

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diets
vertebrates
Nutrition
Vertebrates
Diet
Microbiota
Dysbiosis
Smegmamorpha
fishes
Fish
mice
Fishes
Chemical analysis
Genotype
Perches
Gastrointestinal Microbiome
harbors
microorganisms
Ports and harbors
Individuality

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Bolnick, D. I., Snowberg, L. K., Hirsch, P. E., Lauber, C. L., Org, E., Parks, B., ... Svanbäck, R. (2014). Individual diet has sex-dependent effects on vertebrate gut microbiota. Nature Communications, 5, [4500]. https://doi.org/10.1038/ncomms5500

Individual diet has sex-dependent effects on vertebrate gut microbiota. / Bolnick, Daniel I.; Snowberg, Lisa K.; Hirsch, Philipp E.; Lauber, Christian L.; Org, Elin; Parks, Brian; Lusis, Aldons J.; Knight, Rob; Caporaso, James G; Svanbäck, Richard.

In: Nature Communications, Vol. 5, 4500, 29.07.2014.

Research output: Contribution to journalArticle

Bolnick, DI, Snowberg, LK, Hirsch, PE, Lauber, CL, Org, E, Parks, B, Lusis, AJ, Knight, R, Caporaso, JG & Svanbäck, R 2014, 'Individual diet has sex-dependent effects on vertebrate gut microbiota', Nature Communications, vol. 5, 4500. https://doi.org/10.1038/ncomms5500
Bolnick DI, Snowberg LK, Hirsch PE, Lauber CL, Org E, Parks B et al. Individual diet has sex-dependent effects on vertebrate gut microbiota. Nature Communications. 2014 Jul 29;5. 4500. https://doi.org/10.1038/ncomms5500
Bolnick, Daniel I. ; Snowberg, Lisa K. ; Hirsch, Philipp E. ; Lauber, Christian L. ; Org, Elin ; Parks, Brian ; Lusis, Aldons J. ; Knight, Rob ; Caporaso, James G ; Svanbäck, Richard. / Individual diet has sex-dependent effects on vertebrate gut microbiota. In: Nature Communications. 2014 ; Vol. 5.
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