Immunological variability associated with experimentally-induced positive and negative affective states

Ann D. Futterman, Margaret E. Kemeny, David Shapiro, William Polonsky, John L. Fahey

Research output: Contribution to journalArticle

31 Scopus citations


Functional and phenotypic immunological parameters were examined immediately before, after, and 30 minutes after experimentally-induced short-term positive (happiness) and negative (anxiety, depression) affective states and a neutral state, in five healthy subjects. Results indicated that all affective states induced more immune fluctuations (regardless of the direction) than the neutral state. Furthermore, among the affective states, anxiety induced the most immunological variability and depression the least.

Original languageEnglish (US)
Pages (from-to)231-238
Number of pages8
JournalPsychological Medicine
Issue number1
StatePublished - Feb 1992


ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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