Identifying sources of human exposure to plague

Jennifer L. Lowell, David M Wagner, Bakyt Atshabar, Michael F. Antolin, Amy J. Vogler, Paul S Keim, May C. Chu, Kenneth L. Gage

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Yersinia pestis, the etiologic agent of plague, has shaped the course of human history, killing millions of people in three major pandemics. This bacterium is still endemic in parts of Asia, Africa, and the Americas, where it poses a natural disease threat to human populations. Y. pestis has also recently received attention as a possible bioterrorism agent. Thus, rapid methods to distinguish between bioterrorism and naturally occurring plague infections are of major importance. Our study is the first to demonstrate that variable-number tandem repeats (VNTRs) in the Y. pestis genome can link human case isolates to those obtained from suspected environmental sources of infection. We demonstrate the valuable utility of VNTR markers in epidemiological investigations of naturally occurring plague and the forensic analysis of possible bioterrorism events.

Original languageEnglish (US)
Pages (from-to)650-656
Number of pages7
JournalJournal of Clinical Microbiology
Volume43
Issue number2
DOIs
StatePublished - Feb 2005

Fingerprint

Yersinia pestis
Plague
Bioterrorism
Minisatellite Repeats
Biological Warfare Agents
Pandemics
Infection
History
Genome
Bacteria
Population

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Lowell, J. L., Wagner, D. M., Atshabar, B., Antolin, M. F., Vogler, A. J., Keim, P. S., ... Gage, K. L. (2005). Identifying sources of human exposure to plague. Journal of Clinical Microbiology, 43(2), 650-656. https://doi.org/10.1128/JCM.43.2.650-656.2005

Identifying sources of human exposure to plague. / Lowell, Jennifer L.; Wagner, David M; Atshabar, Bakyt; Antolin, Michael F.; Vogler, Amy J.; Keim, Paul S; Chu, May C.; Gage, Kenneth L.

In: Journal of Clinical Microbiology, Vol. 43, No. 2, 02.2005, p. 650-656.

Research output: Contribution to journalArticle

Lowell, JL, Wagner, DM, Atshabar, B, Antolin, MF, Vogler, AJ, Keim, PS, Chu, MC & Gage, KL 2005, 'Identifying sources of human exposure to plague', Journal of Clinical Microbiology, vol. 43, no. 2, pp. 650-656. https://doi.org/10.1128/JCM.43.2.650-656.2005
Lowell, Jennifer L. ; Wagner, David M ; Atshabar, Bakyt ; Antolin, Michael F. ; Vogler, Amy J. ; Keim, Paul S ; Chu, May C. ; Gage, Kenneth L. / Identifying sources of human exposure to plague. In: Journal of Clinical Microbiology. 2005 ; Vol. 43, No. 2. pp. 650-656.
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