Hypothalamic-pituitary-adrenal axis response and recovery from high-intensity exercise in women

Effects of aging and fitness

Tinna Traustadottir, Pamela R Bosch, Timasue Cantu, Kathleen S. Matt

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

This study tested the hypotheses that aging is associated with prolonged recovery after a challenge to the hypothalamus-pituitary-adrenal axis (acute exercise) and that aerobic fitness is associated with a blunting of the age-related loss of negative feedback sensitivity. Young (27 ± 2.8 yr, n = 9), older (64.6 ± 1.4 yr, n = 11), and older-fit women (66.3 ± 2.2 yr, n = 11) underwent a short bout of treadmill exercise at high (but submaximal) intensity. The exercise trial elicited significant increases in heart rate, blood pressure, ACTH, and cortisol (P < 0.001). Although the young and the older women exhibited similar cortisol response to the trial and throughout the recovery period, the older women had a slower decrease of ACTH levels (P < 0.05), suggesting reduced negative feedback sensitivity with aging. Between the two groups of older women, the older-fit group had significantly greater rate of recovery of ACTH levels (P < 0.05) compared with the older unfit women. However, older fit women had greater cortisol production during the recovery period (P < 0.05), suggesting greater adrenal sensitivity to ACTH. These results suggest that aging is associated with changes in the dynamic function of the hypothalamic-pituitary-adrenal axis and that these changes are attenuated by aerobic fitness.

Original languageEnglish (US)
Pages (from-to)3248-3254
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number7
DOIs
StatePublished - Jul 2004
Externally publishedYes

Fingerprint

Adrenocorticotropic Hormone
Aging of materials
Exercise
Hydrocortisone
Recovery
Feedback
Exercise equipment
Blood pressure
Hypothalamus
Heart Rate
Blood Pressure

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{781cfaf17aa641149d23de45b2fde709,
title = "Hypothalamic-pituitary-adrenal axis response and recovery from high-intensity exercise in women: Effects of aging and fitness",
abstract = "This study tested the hypotheses that aging is associated with prolonged recovery after a challenge to the hypothalamus-pituitary-adrenal axis (acute exercise) and that aerobic fitness is associated with a blunting of the age-related loss of negative feedback sensitivity. Young (27 ± 2.8 yr, n = 9), older (64.6 ± 1.4 yr, n = 11), and older-fit women (66.3 ± 2.2 yr, n = 11) underwent a short bout of treadmill exercise at high (but submaximal) intensity. The exercise trial elicited significant increases in heart rate, blood pressure, ACTH, and cortisol (P < 0.001). Although the young and the older women exhibited similar cortisol response to the trial and throughout the recovery period, the older women had a slower decrease of ACTH levels (P < 0.05), suggesting reduced negative feedback sensitivity with aging. Between the two groups of older women, the older-fit group had significantly greater rate of recovery of ACTH levels (P < 0.05) compared with the older unfit women. However, older fit women had greater cortisol production during the recovery period (P < 0.05), suggesting greater adrenal sensitivity to ACTH. These results suggest that aging is associated with changes in the dynamic function of the hypothalamic-pituitary-adrenal axis and that these changes are attenuated by aerobic fitness.",
author = "Tinna Traustadottir and Bosch, {Pamela R} and Timasue Cantu and Matt, {Kathleen S.}",
year = "2004",
month = "7",
doi = "10.1210/jc.2003-031713",
language = "English (US)",
volume = "89",
pages = "3248--3254",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "7",

}

TY - JOUR

T1 - Hypothalamic-pituitary-adrenal axis response and recovery from high-intensity exercise in women

T2 - Effects of aging and fitness

AU - Traustadottir, Tinna

AU - Bosch, Pamela R

AU - Cantu, Timasue

AU - Matt, Kathleen S.

PY - 2004/7

Y1 - 2004/7

N2 - This study tested the hypotheses that aging is associated with prolonged recovery after a challenge to the hypothalamus-pituitary-adrenal axis (acute exercise) and that aerobic fitness is associated with a blunting of the age-related loss of negative feedback sensitivity. Young (27 ± 2.8 yr, n = 9), older (64.6 ± 1.4 yr, n = 11), and older-fit women (66.3 ± 2.2 yr, n = 11) underwent a short bout of treadmill exercise at high (but submaximal) intensity. The exercise trial elicited significant increases in heart rate, blood pressure, ACTH, and cortisol (P < 0.001). Although the young and the older women exhibited similar cortisol response to the trial and throughout the recovery period, the older women had a slower decrease of ACTH levels (P < 0.05), suggesting reduced negative feedback sensitivity with aging. Between the two groups of older women, the older-fit group had significantly greater rate of recovery of ACTH levels (P < 0.05) compared with the older unfit women. However, older fit women had greater cortisol production during the recovery period (P < 0.05), suggesting greater adrenal sensitivity to ACTH. These results suggest that aging is associated with changes in the dynamic function of the hypothalamic-pituitary-adrenal axis and that these changes are attenuated by aerobic fitness.

AB - This study tested the hypotheses that aging is associated with prolonged recovery after a challenge to the hypothalamus-pituitary-adrenal axis (acute exercise) and that aerobic fitness is associated with a blunting of the age-related loss of negative feedback sensitivity. Young (27 ± 2.8 yr, n = 9), older (64.6 ± 1.4 yr, n = 11), and older-fit women (66.3 ± 2.2 yr, n = 11) underwent a short bout of treadmill exercise at high (but submaximal) intensity. The exercise trial elicited significant increases in heart rate, blood pressure, ACTH, and cortisol (P < 0.001). Although the young and the older women exhibited similar cortisol response to the trial and throughout the recovery period, the older women had a slower decrease of ACTH levels (P < 0.05), suggesting reduced negative feedback sensitivity with aging. Between the two groups of older women, the older-fit group had significantly greater rate of recovery of ACTH levels (P < 0.05) compared with the older unfit women. However, older fit women had greater cortisol production during the recovery period (P < 0.05), suggesting greater adrenal sensitivity to ACTH. These results suggest that aging is associated with changes in the dynamic function of the hypothalamic-pituitary-adrenal axis and that these changes are attenuated by aerobic fitness.

UR - http://www.scopus.com/inward/record.url?scp=3242716537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242716537&partnerID=8YFLogxK

U2 - 10.1210/jc.2003-031713

DO - 10.1210/jc.2003-031713

M3 - Article

VL - 89

SP - 3248

EP - 3254

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -