Humans and evolutionary and ecological forces shaped the phylogeography of recently emerged diseases

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70 Citations (Scopus)

Abstract

The development of human civilizations and global commerce has led to the emergence and worldwide circulation of many infectious diseases. Anthrax, plague and tularaemia are three zoonotic diseases that have been intensely studied through genome characterization of the causative species and phylogeographical analyses. A few highly fit genotypes in each species represent the causative agents for most of the observed disease cases. Together, mutational and selective forces create highly adapted pathogens, but this must be coupled with ecological opportunities for global expansion. This Review describes the distributions of the bacteria that cause anthrax, plague and tularaemia and investigates the forces that created clonal structures in these species.

Original languageEnglish (US)
Pages (from-to)813-821
Number of pages9
JournalNature Reviews Microbiology
Volume7
Issue number11
DOIs
StatePublished - 2009

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Phylogeography
Tularemia
Anthrax
Plague
Civilization
Zoonoses
Human Development
Communicable Diseases
Genotype
Genome
Bacteria

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

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