Human ECM for devices and therapeutics

Gail Naughton, Robert Kellar

Research output: Contribution to specialist publicationArticle

4 Scopus citations

Abstract

Some of the views on a human extracellular matrix (hECM) materials, which is manufactured to mimic characteristics of the embryonic environment, are discussed. The hECM is developed through a tissue-engineering technology using neonatal fibroblasts to create a nonsoluble matrix materials, similar to the embryonic structural tissue that provide the framework for development of blood, skin, muscle, and bone. Human ECM does not carry any risk of an allergic reaction or the transmission of animal viruses. It can be used as a coating for implants to improve tissue ingrowth, vehicles for cell delivery, injectables for soft-tissue augmentation, and tissue regeneration patches. The production of the hECM can be encourage by exploring growing neonatal fibroblasts under fetal-like conditions. This material is a by-product of the culture process and is being evaluated for a variety of clinical and research use.

Original languageEnglish (US)
Pages102-109
Number of pages8
Volume30
No5
Specialist publicationMedical Device and Diagnostic Industry
StatePublished - May 1 2008
Externally publishedYes

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ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanical Engineering

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