Host persistence or extinction from emerging infectious disease

insights from white-nose syndrome in endemic and invading regions

Joseph R. Hoyt, Kate E. Langwig, Keping Sun, Guanjun Lu, Katy L. Parise, Tinglei Jiang, Winifred F. Frick, Jeffrey T Foster, Jiang Feng, A. Marm Kilpatrick

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Predicting species' fates following the introduction of a novel pathogen is a significant and growing problem in conservation. Comparing disease dynamics between introduced and endemic regions can offer insight into which naive hosts will persist or go extinct, with disease acting as a filter on host communities. We examined four hypothesized mechanisms for host-pathogen persistence by comparing host infection patterns and environmental reservoirs for Pseudogymnoascus destructans (the causative agent of white-nose syndrome) in Asia, an endemic region, and North America, where the pathogen has recently invaded. Although colony sizes of bats and hibernacula temperatures were very similar, both infection prevalence and fungal loads were much lower on bats and in the environment in Asia than North America. These results indicate that transmission intensity and pathogen growth are lower in Asia, likely due to higher host resistance to pathogen growth in this endemic region, and not due to host tolerance, lower transmission due to smaller populations, or lower environmentally driven pathogen growth rate. Disease filtering also appears to be favouring initially resistant species in North America. More broadly, determining the mechanisms allowing species persistence in endemic regions can help identify species at greater risk of extinction in introduced regions, and determine the consequences for disease dynamics and host-pathogen coevolution.

Original languageEnglish (US)
Pages (from-to)20152861
Number of pages1
JournalProceedings. Biological sciences
Volume283
Issue number1826
DOIs
StatePublished - Mar 16 2016

Fingerprint

Emerging Communicable Diseases
emerging diseases
infectious disease
Pathogens
Nose
extinction
persistence
pathogen
North America
pathogens
Growth
Infectious Disease Transmission
Mycoses
bat
Chiroptera
coevolution
hibernation
Temperature
white-nose syndrome
infection

Keywords

  • emerging infectious disease
  • Geomyces destructans
  • Pseudogymnoascus destructans
  • resistance
  • tolerance
  • White-nose syndrome

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Host persistence or extinction from emerging infectious disease : insights from white-nose syndrome in endemic and invading regions. / Hoyt, Joseph R.; Langwig, Kate E.; Sun, Keping; Lu, Guanjun; Parise, Katy L.; Jiang, Tinglei; Frick, Winifred F.; Foster, Jeffrey T; Feng, Jiang; Marm Kilpatrick, A.

In: Proceedings. Biological sciences, Vol. 283, No. 1826, 16.03.2016, p. 20152861.

Research output: Contribution to journalArticle

Hoyt, JR, Langwig, KE, Sun, K, Lu, G, Parise, KL, Jiang, T, Frick, WF, Foster, JT, Feng, J & Marm Kilpatrick, A 2016, 'Host persistence or extinction from emerging infectious disease: insights from white-nose syndrome in endemic and invading regions', Proceedings. Biological sciences, vol. 283, no. 1826, pp. 20152861. https://doi.org/10.1098/rspb.2015.2861
Hoyt, Joseph R. ; Langwig, Kate E. ; Sun, Keping ; Lu, Guanjun ; Parise, Katy L. ; Jiang, Tinglei ; Frick, Winifred F. ; Foster, Jeffrey T ; Feng, Jiang ; Marm Kilpatrick, A. / Host persistence or extinction from emerging infectious disease : insights from white-nose syndrome in endemic and invading regions. In: Proceedings. Biological sciences. 2016 ; Vol. 283, No. 1826. pp. 20152861.
@article{5329731775f64c6a8f138e84f3e391e0,
title = "Host persistence or extinction from emerging infectious disease: insights from white-nose syndrome in endemic and invading regions",
abstract = "Predicting species' fates following the introduction of a novel pathogen is a significant and growing problem in conservation. Comparing disease dynamics between introduced and endemic regions can offer insight into which naive hosts will persist or go extinct, with disease acting as a filter on host communities. We examined four hypothesized mechanisms for host-pathogen persistence by comparing host infection patterns and environmental reservoirs for Pseudogymnoascus destructans (the causative agent of white-nose syndrome) in Asia, an endemic region, and North America, where the pathogen has recently invaded. Although colony sizes of bats and hibernacula temperatures were very similar, both infection prevalence and fungal loads were much lower on bats and in the environment in Asia than North America. These results indicate that transmission intensity and pathogen growth are lower in Asia, likely due to higher host resistance to pathogen growth in this endemic region, and not due to host tolerance, lower transmission due to smaller populations, or lower environmentally driven pathogen growth rate. Disease filtering also appears to be favouring initially resistant species in North America. More broadly, determining the mechanisms allowing species persistence in endemic regions can help identify species at greater risk of extinction in introduced regions, and determine the consequences for disease dynamics and host-pathogen coevolution.",
keywords = "emerging infectious disease, Geomyces destructans, Pseudogymnoascus destructans, resistance, tolerance, White-nose syndrome",
author = "Hoyt, {Joseph R.} and Langwig, {Kate E.} and Keping Sun and Guanjun Lu and Parise, {Katy L.} and Tinglei Jiang and Frick, {Winifred F.} and Foster, {Jeffrey T} and Jiang Feng and {Marm Kilpatrick}, A.",
year = "2016",
month = "3",
day = "16",
doi = "10.1098/rspb.2015.2861",
language = "English (US)",
volume = "283",
pages = "20152861",
journal = "Proceedings of the Royal Society B: Biological Sciences",
issn = "0800-4622",
publisher = "Royal Society of London",
number = "1826",

}

TY - JOUR

T1 - Host persistence or extinction from emerging infectious disease

T2 - insights from white-nose syndrome in endemic and invading regions

AU - Hoyt, Joseph R.

AU - Langwig, Kate E.

AU - Sun, Keping

AU - Lu, Guanjun

AU - Parise, Katy L.

AU - Jiang, Tinglei

AU - Frick, Winifred F.

AU - Foster, Jeffrey T

AU - Feng, Jiang

AU - Marm Kilpatrick, A.

PY - 2016/3/16

Y1 - 2016/3/16

N2 - Predicting species' fates following the introduction of a novel pathogen is a significant and growing problem in conservation. Comparing disease dynamics between introduced and endemic regions can offer insight into which naive hosts will persist or go extinct, with disease acting as a filter on host communities. We examined four hypothesized mechanisms for host-pathogen persistence by comparing host infection patterns and environmental reservoirs for Pseudogymnoascus destructans (the causative agent of white-nose syndrome) in Asia, an endemic region, and North America, where the pathogen has recently invaded. Although colony sizes of bats and hibernacula temperatures were very similar, both infection prevalence and fungal loads were much lower on bats and in the environment in Asia than North America. These results indicate that transmission intensity and pathogen growth are lower in Asia, likely due to higher host resistance to pathogen growth in this endemic region, and not due to host tolerance, lower transmission due to smaller populations, or lower environmentally driven pathogen growth rate. Disease filtering also appears to be favouring initially resistant species in North America. More broadly, determining the mechanisms allowing species persistence in endemic regions can help identify species at greater risk of extinction in introduced regions, and determine the consequences for disease dynamics and host-pathogen coevolution.

AB - Predicting species' fates following the introduction of a novel pathogen is a significant and growing problem in conservation. Comparing disease dynamics between introduced and endemic regions can offer insight into which naive hosts will persist or go extinct, with disease acting as a filter on host communities. We examined four hypothesized mechanisms for host-pathogen persistence by comparing host infection patterns and environmental reservoirs for Pseudogymnoascus destructans (the causative agent of white-nose syndrome) in Asia, an endemic region, and North America, where the pathogen has recently invaded. Although colony sizes of bats and hibernacula temperatures were very similar, both infection prevalence and fungal loads were much lower on bats and in the environment in Asia than North America. These results indicate that transmission intensity and pathogen growth are lower in Asia, likely due to higher host resistance to pathogen growth in this endemic region, and not due to host tolerance, lower transmission due to smaller populations, or lower environmentally driven pathogen growth rate. Disease filtering also appears to be favouring initially resistant species in North America. More broadly, determining the mechanisms allowing species persistence in endemic regions can help identify species at greater risk of extinction in introduced regions, and determine the consequences for disease dynamics and host-pathogen coevolution.

KW - emerging infectious disease

KW - Geomyces destructans

KW - Pseudogymnoascus destructans

KW - resistance

KW - tolerance

KW - White-nose syndrome

UR - http://www.scopus.com/inward/record.url?scp=85015595161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015595161&partnerID=8YFLogxK

U2 - 10.1098/rspb.2015.2861

DO - 10.1098/rspb.2015.2861

M3 - Article

VL - 283

SP - 20152861

JO - Proceedings of the Royal Society B: Biological Sciences

JF - Proceedings of the Royal Society B: Biological Sciences

SN - 0800-4622

IS - 1826

ER -