Genomics reveals historic and contemporary transmission dynamics of a bacterial disease among wildlife and livestock

Pauline L. Kamath, Jeffrey T Foster, Kevin P. Drees, Gordon Luikart, Christine Quance, Neil J. Anderson, P. Ryan Clarke, Eric K. Cole, Mark L. Drew, William H. Edwards, Jack C. Rhyan, John J. Treanor, Rick L. Wallen, Patrick J. White, Suelee Robbe-Austerman, Paul C. Cross

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Whole-genome sequencing has provided fundamental insights into infectious disease epidemiology, but has rarely been used for examining transmission dynamics of a bacterial pathogen in wildlife. In the Greater Yellowstone Ecosystem (GYE), outbreaks of brucellosis have increased in cattle along with rising seroprevalence in elk. Here we use a genomic approach to examine Brucella abortus evolution, cross-species transmission and spatial spread in the GYE. We find that brucellosis was introduced into wildlife in this region at least five times. The diffusion rate varies among Brucella lineages (∼3 to 8 km per year) and over time. We also estimate 12 host transitions from bison to elk, and 5 from elk to bison. Our results support the notion that free-ranging elk are currently a self-sustaining brucellosis reservoir and the source of livestock infections, and that control measures in bison are unlikely to affect the dynamics of unrelated strains circulating in nearby elk populations.

Original languageEnglish (US)
Article number11448
JournalNature Communications
Volume7
DOIs
StatePublished - May 11 2016

Fingerprint

bacterial diseases
Bison
wildlife
livestock
Brucellosis
ecosystems
Livestock
infectious diseases
Genomics
Ecosystems
Agriculture
cattle
epidemiology
Epidemiology
sequencing
Ecosystem
pathogens
genome
sustaining
Pathogens

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Genomics reveals historic and contemporary transmission dynamics of a bacterial disease among wildlife and livestock. / Kamath, Pauline L.; Foster, Jeffrey T; Drees, Kevin P.; Luikart, Gordon; Quance, Christine; Anderson, Neil J.; Clarke, P. Ryan; Cole, Eric K.; Drew, Mark L.; Edwards, William H.; Rhyan, Jack C.; Treanor, John J.; Wallen, Rick L.; White, Patrick J.; Robbe-Austerman, Suelee; Cross, Paul C.

In: Nature Communications, Vol. 7, 11448, 11.05.2016.

Research output: Contribution to journalArticle

Kamath, PL, Foster, JT, Drees, KP, Luikart, G, Quance, C, Anderson, NJ, Clarke, PR, Cole, EK, Drew, ML, Edwards, WH, Rhyan, JC, Treanor, JJ, Wallen, RL, White, PJ, Robbe-Austerman, S & Cross, PC 2016, 'Genomics reveals historic and contemporary transmission dynamics of a bacterial disease among wildlife and livestock', Nature Communications, vol. 7, 11448. https://doi.org/10.1038/ncomms11448
Kamath, Pauline L. ; Foster, Jeffrey T ; Drees, Kevin P. ; Luikart, Gordon ; Quance, Christine ; Anderson, Neil J. ; Clarke, P. Ryan ; Cole, Eric K. ; Drew, Mark L. ; Edwards, William H. ; Rhyan, Jack C. ; Treanor, John J. ; Wallen, Rick L. ; White, Patrick J. ; Robbe-Austerman, Suelee ; Cross, Paul C. / Genomics reveals historic and contemporary transmission dynamics of a bacterial disease among wildlife and livestock. In: Nature Communications. 2016 ; Vol. 7.
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