Genomic Characterization of Newly Completed Genomes of Botulinum Neurotoxin-Producing Species from Argentina, Australia, and Africa

Theresa J. Smith, Gary Xie, Charles H.D. Williamson, Karen K. Hill, Rafael A. Fernández, Jason W. Sahl, Paul Keim, Shannon L. Johnson, Luis Delaye

Research output: Contribution to journalArticle

Abstract

Botulinum neurotoxin-producing clostridia are diverse in the types of toxins they produce as well as in their overall genomic composition. They are globally distributed, with prevalent species and toxin types found within distinct geographic regions, but related strains containing the same toxin types may also be located on distinct continents. The mechanisms behind the spread of these bacteria and the independent movements of their bont genes may be understood through examination of their genetic backgrounds. The generation of 15 complete genomic sequences from bacteria isolated in Argentina, Australia, and Africa allows for a thorough examination of genome features, including overall relationships, bont gene cluster locations and arrangements, and plasmid comparisons, in bacteria isolated from various areas in the southern hemisphere. Insights gained from these examinations provide an understanding of the mechanisms behind the independent movements of these elements among distinct species.

Original languageEnglish (US)
Pages (from-to)229-242
Number of pages14
JournalGenome Biology and Evolution
Volume12
Issue number3
DOIs
StatePublished - Mar 17 2020

Keywords

  • Africa
  • Argentina
  • Australia
  • botulinum neurotoxin producing
  • clostridia

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics

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    Smith, T. J., Xie, G., Williamson, C. H. D., Hill, K. K., Fernández, R. A., Sahl, J. W., Keim, P., Johnson, S. L., & Delaye, L. (2020). Genomic Characterization of Newly Completed Genomes of Botulinum Neurotoxin-Producing Species from Argentina, Australia, and Africa. Genome Biology and Evolution, 12(3), 229-242. https://doi.org/10.1093/gbe/evaa043