Forensic analysis in bacterial pathogens

Paul Keim, Jason W. Sahl, Talima Pearson, Amy Vogler, Charles H. Williamson, Dawn Birdsell, Richard T. Okinaka, Jeffrey T. Foster, David M. Wagner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bacterial pathogens have been and continue to be important targets for microbial forensics. They also represent distinct biological entities that have their own unique biology, genomes, and population genetics. The precise identification of the bacterial agent (genus and species) and well as the particular strain has recently focused on genomic analysis. In a microbial forensic analysis, this can involve multiple hierarchical levels ranging down to a single production batch of cells. A combination of SNPs and hypervariable loci has proven useful in the past, though more and more it is simple a whole genome analysis of SNPs. The population genomics of Bacillus anthracis, Yersinia pestis, Francisella tularensis, Brucella sp., Burkholderia pseudomallei and Clostridium botulinum are presented in a microbial forensics context.

Original languageEnglish (US)
Title of host publicationMicrobial Forensics
PublisherElsevier
Pages123-140
Number of pages18
ISBN (Electronic)9780128153796
DOIs
StatePublished - Jan 1 2019

Keywords

  • Anthrax
  • Botulism
  • Genome
  • MLVA
  • Mutation rate
  • Plague
  • SNPs
  • Tularemia

ASJC Scopus subject areas

  • Social Sciences(all)

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