Extreme sensitivity to ultraviolet light in the fungal pathogen causing white-nose syndrome of bats

Jonathan M. Palmer, Kevin P. Drees, Jeffrey T Foster, Daniel L. Lindner

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Bat white-nose syndrome (WNS), caused by the fungal pathogen Pseudogymnoascus destructans, has decimated North American hibernating bats since its emergence in 2006. Here, we utilize comparative genomics to examine the evolutionary history of this pathogen in comparison to six closely related nonpathogenic species. P. destructans displays a large reduction in carbohydrate-utilizing enzymes (CAZymes) and in the predicted secretome (~50%), and an increase in lineage-specific genes. The pathogen has lost a key enzyme, UVE1, in the alternate excision repair (AER) pathway, which is known to contribute to repair of DNA lesions induced by ultraviolet (UV) light. Consistent with a nonfunctional AER pathway, P. destructans is extremely sensitive to UV light, as well as the DNA alkylating agent methyl methanesulfonate (MMS). The differential susceptibility of P. destructans to UV light in comparison to other hibernacula-inhabiting fungi represents a potential "Achilles' heel" of P. destructans that might be exploited for treatment of bats with WNS.

Original languageEnglish (US)
Article number2441
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

bats
pathogens
Pathogens
Ultraviolet Rays
Nose
DNA Repair
ultraviolet radiation
Repair
enzymes
sensitivity
deoxyribonucleic acid
Methyl Methanesulfonate
fungi
Alkylating Agents
DNA
carbohydrates
Enzymes
Genomics
Fungi
genes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Extreme sensitivity to ultraviolet light in the fungal pathogen causing white-nose syndrome of bats. / Palmer, Jonathan M.; Drees, Kevin P.; Foster, Jeffrey T; Lindner, Daniel L.

In: Nature Communications, Vol. 9, No. 1, 2441, 01.12.2018.

Research output: Contribution to journalArticle

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