Evidence for archaic Asian ancestry on the human X chromosome

Daniel Garrigan, Zahra Mobasher, Tesa Severson, Jason A Wilder, Michael F. Hammer

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The human RRM2P4 pseudogene has a pattern of nucleotide polymorphism that is unlike any locus published to date. A gene tree constructed from a 2.4-kb fragment of the RRM2P4 locus sequenced in a sample of 41 worldwide humans clearly roots in East Asia and has a most-recent common ancestor approximately 2 Myr before present. The presence of this basal lineage exclusively in Asia results in higher nucleotide diversity among non-Africans than among Africans. A global survey of a single-nucleotide polymorphism that is diagnostic for the basal, Asian lineage in 570 individuals shows that it occurs at frequencies up to 53% in south China, whereas only one of 177 surveyed Africans carries this archaic lineage. We suggest that this ancient lineage is a remnant of introgressive hybridization between expanding anatomically modern humans emerging from Africa and archaic populations in Eurasia.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalMolecular Biology and Evolution
Volume22
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

Fingerprint

Chromosomes, Human, X
X chromosome
Chromosomes
ancestry
chromosome
polymorphism
Nucleotides
Polymorphism
common ancestry
nucleotides
Pseudogenes
loci
Far East
pseudogenes
Eurasia
East Asia
introgression
single nucleotide polymorphism
Single Nucleotide Polymorphism
gene

Keywords

  • Human origins
  • Hybridization
  • Polymorphism
  • Population subdivision
  • Pseudogene

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Genetics(clinical)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Molecular Biology

Cite this

Evidence for archaic Asian ancestry on the human X chromosome. / Garrigan, Daniel; Mobasher, Zahra; Severson, Tesa; Wilder, Jason A; Hammer, Michael F.

In: Molecular Biology and Evolution, Vol. 22, No. 2, 02.2005, p. 189-192.

Research output: Contribution to journalArticle

Garrigan, Daniel ; Mobasher, Zahra ; Severson, Tesa ; Wilder, Jason A ; Hammer, Michael F. / Evidence for archaic Asian ancestry on the human X chromosome. In: Molecular Biology and Evolution. 2005 ; Vol. 22, No. 2. pp. 189-192.
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